Lactoferrin or a Fragment Thereof Inhibits the Endotoxin-Induced Interleukin-6 Response in Human Monocytic Cells
| Autor: | Lars Å. Hanson, Inger Mattsby-Baltzer, J Elverfors, A Roseanu, C. Motas, I Engberg |
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| Rok vydání: | 1996 |
| Předmět: |
Lipopolysaccharides
Lipopolysaccharide medicine.medical_treatment Monocytes Cell Line chemistry.chemical_compound Cell Wall Escherichia coli medicine Humans Bioassay Interleukin 6 biology Interleukin-6 Lactoferrin Monocyte Molecular biology Peptide Fragments Cytokine medicine.anatomical_structure Biochemistry chemistry Cell culture Pediatrics Perinatology and Child Health biology.protein Biological Assay Breast feeding |
| Zdroj: | Pediatric Research. 40:257-262 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-199608000-00011 |
| Popis: | Human milk is in several ways anti-inflammatory. This study investigates whether or not human milk lactoferrin (LF) in comparison with bovine LF can affect the IL-6 release from human cells. Human, as well as bovine, LF and a bactericidal pepsin-derived fragment of bovine LF (lactoferricin B) were found to suppress the IL-6 response in a monocytic cell line (THP-1) when stimulated by lipopolysaccharide (LPS). The suppression of bovine LF was similar to or higher than that of human LF. Lactoferricin B was the strongest inhibitor of the LPS-induced IL-6 response. A time-dependence regarding the inhibitory capacity of LF was found. For human LF, the strongest inhibition was observed when added 15-30 min after the addition of LPS. Addition of LF before the LPS induced an approximately 45% reduction of the IL-6 response. The results suggest an anti-inflammatory activity of both human and bovine LF, and of the LF fragment lactoferricin B through their suppressive effects on the cytokine release. |
| Databáze: | OpenAIRE |
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