Unusual Presentation of Thrombotic Thrombocytopenic Purpura in a Newly Diagnosed Pediatric Patient With Systemic Lupus Erythematosus in the Setting of MIS-C

Autor:	Eman T, Al-Antary, Rewa, Arar, Yogindra, Persaud, Basil M, Fathalla, Madhvi, Rajpurkar, Kanta, Bhambhani
Rok vydání:	2021
Předmět:	Adult Purpura Thrombotic Thrombocytopenic Oncology Pediatrics Perinatology and Child Health COVID-19 Humans Lupus Erythematosus Systemic Hematology Child Systemic Inflammatory Response Syndrome
Zdroj:	Journal of Pediatric Hematology/Oncology. 44:e812-e815
ISSN:	1077-4114
Popis:	The understanding of coronavirus disease 2019 (COVID-19) immune dysregulation is evolving. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with alternations in both innate and adaptive immunity, probably caused by a complex interplay of genetics and environmental exposure with various triggers. A rare hematological complication of SLE as well as recently reported in an adult with COVID-19 is thrombotic thrombocytopenic purpura. We report a pediatric case with features suggestive of the multisystem inflammatory syndrome in children with coronary artery ectasia, thrombotic thrombocytopenic purpura, and new-onset SLE.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37dae1d74d58a717be936bde1346aa5d https://doi.org/10.1097/mph.0000000000002370 Zobrazit plný text záznamu