Preoperative 18F-FDG PET/CT in Pheochromocytomas and Paragangliomas Allows for Precision Surgery
| Autor: | Apostolos Gaitanidis, Dhaval Patel, Pavel Nockel, Electron Kebebew, Naris Nilubol, Mustapha El Lakis, Roxanne Merkel, Karel Pacak, Tamara Prodanov |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Adolescent Adrenal Gland Neoplasms Computed tomography Pheochromocytoma 030204 cardiovascular system & hematology Preoperative care Article Paraganglioma Young Adult 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Preoperative Care medicine Humans In patient Prospective Studies Precision Medicine Child neoplasms Aged Fluorodeoxyglucose medicine.diagnostic_test business.industry Adrenalectomy Middle Aged medicine.disease Precision surgery carbohydrates (lipids) Positron emission tomography 030220 oncology & carcinogenesis Female Surgery Fdg pet ct Radiopharmaceuticals Nuclear medicine business medicine.drug |
| Zdroj: | Ann Surg |
| ISSN: | 1528-1140 0003-4932 |
| Popis: | BACKGROUND: Fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) imaging is recommended in patients with metastatic pheochromocytoma (PC) and paraganglioma (PGL). There are no data on whether routine preoperative (18)F-FDG PET/CT in all patients with PC/PGL impacts surgical management. OBJECTIVE: The aim of this study was to determine whether routine preoperative (18)F-FDG PET/CT imaging affects the surgical management of patients with PC/PGLs. METHODS: We analyzed clinical, biochemical, genetic, and anatomic imaging data in 93 consecutive patients with PC/PGL who collectively underwent a total of 100 operations and who had preoperative (18)F-FDG PET/CT imaging. RESULTS: Of 100 operations, preoperative (18)F-FDG PET/CT showed additional lesions compared to anatomic imaging in 15 cases. These patients were more likely to undergo an open surgical approach (P < 0.05). Presence of genetic mutation, redo operations, sex, age, or tumor size had no significant association with finding additional lesions on (18)F-FDG PET/CT. CONCLUSIONS: Additional lesions detected on preoperative (18)F-FDG-PET/CT imaging have an impact on the surgical approach in patients with PC/PGLs. Therefore, surgeons should routinely obtain (18)F-FDG-PET/CT imaging in patients with PC/PGL to allow for a more precise surgical intervention. |
| Databáze: | OpenAIRE |
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