Diflunisal and blood acid base status in the rabbit
| Autor: | Barbara J. Pleuvry, J E Smith, E G Bradshaw |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Bicarbonate Metabolic alkalosis Pharmaceutical Science Diflunisal Acid–base homeostasis pCO2 chemistry.chemical_compound Internal medicine medicine Animals Pharmacology Acid-Base Equilibrium Aspirin Metabolic acidosis Carbon Dioxide Hydrogen-Ion Concentration medicine.disease Salicylates Surgery Endocrinology chemistry Respiratory alkalosis Toxicity Female Rabbits medicine.drug |
| Zdroj: | The Journal of pharmacy and pharmacology. 36(3) |
| ISSN: | 0022-3573 |
| Popis: | Both diflunisal and acetylsalicylic acid given orally caused respiratory alkalosis and metabolic acidosis. However the fall in standard bicarbonate was much less in diflunisal-treated rabbits and pH in these animals remained elevated for the duration of the experiment. Whilst the severity of the fall in arterialized venous PCO2 was a good indicator of the degree of acetylsalicylic acid intoxication this was not the case for diflunisal as fatalities occurred with trivial changes in PCO2. Diflunisal toxicity was associated with markedly elevated temperatures. This was not observed in acetylsalicylic acid-treated rabbits. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text