Susceptibility to UV-A and UV-B provocation does not correlate with disease severity of polymorphic light eruption
| Autor: | Christina Antoniou, Tsui Ling, Nikoletta Anastasopoulou, Thomas L. Diepgen, Alexander J. Stratigos, Lesley E. Rhodes, Frank R. de Gruijl, Stan Pavel, Sandra Maria Winhoven, Artiena Soe Janssens |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Allergy Ultraviolet Rays Provocation test Dermatology Disease Severity of Illness Index Predictive Value of Tests Immunopathology Severity of illness medicine Humans Photosensitivity Disorders Skin Skin Tests business.industry Dose-Response Relationship Radiation General Medicine Middle Aged medicine.disease Rash Predictive value of tests Female Disease Susceptibility medicine.symptom Polymorphous light eruption business |
| Zdroj: | Archives of dermatology. 143(5) |
| ISSN: | 0003-987X |
| Popis: | Objective To examine whether the ease of disease provocation by UV-A and/or UV-B radiation correlates with clinical features of polymorphic light eruption (PLE), including those indicative of disease severity. Design Intervention study. Patients One hundred forty-three patients with PLE. Interventions Provocation testing with broadband UV-A and UV-B lamps. Additionally, a range of clinical characteristics of the disorder, including a 5-item PLE severity score, was assessed by questionnaire. Main Outcome Measures Percentage of PLE rash induction by UV-A and UV-B provocation, differences between the skin types, and correlation between the results of provocation and a range of clinical characteristics of the disorder, including a 5-item PLE severity score. Results Rash provocation was seen in 78.3% of patients after UV-A and in 46.7% after UV-B exposure. Neither UV-A nor UV-B provocation showed a significant association with the total 5-item severity score. The UV-B reactivity was associated with a high score on the severity item “number of months affected per year” ( P = .04), whereas UV-A responsiveness showed a tendency for association with facial involvement ( P = .06). Conclusion The objective assessment of UV-A or UV-B susceptibility in this large group of patients showed no significant relationship with clinical disease severity. |
| Databáze: | OpenAIRE |
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