Association of HLA-DQB1*03:01 and DRB1*11:01 with spontaneous clearance of hepatitis C virus in Chinese Li ethnicity, an ethnic group genetically distinct from Chinese Han ethnicity and infected with unique HCV subtype
| Autor: | Xia Rong, Ke Huang, Yongshui Fu, Ru Xu, Jieting Huang, Zhengang Shan, Qiao Liao, Chengyao Li, Qingzhu You, Min Wang |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Linkage disequilibrium China Genotype Hepatitis C virus Human leukocyte antigen Hepacivirus medicine.disease_cause Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Asian People Virology Ethnicity Medicine HLA-DQ beta-Chains Humans Genetic Predisposition to Disease 030212 general & internal medicine Alleles Aged Hepatitis Aged 80 and over HLA-DQB1 business.industry Hepatitis C Hepatitis C Chronic medicine.disease Infectious Diseases Cohort 030211 gastroenterology & hepatology Female Interferons business HLA-DRB1 Chains |
| Zdroj: | Journal of medical virology. 91(10) |
| ISSN: | 1096-9071 |
| Popis: | Specific human leukocyte antigen (HLA) class I and class II alleles have been associated with spontaneous clearance or persistent infection of hepatitis C virus (HCV), which seemed to be restricted by the host's ethnicity and viral genotype. Recently we reported a high prevalence and spontaneous clearance rate of HCV in a cohort of Chinese Li ethnicity who were infected with new variants of HCV genotype 6. In this study, we found that the distribution of HLA class I and class II alleles in HCV infected individuals of Chinese Li ethnicity (n = 143) was distinct from that of Chinese Han ethnicity which was reported in our previous study. HLA-DRB1*11:01 and DQB1*03:01 were more prevalent in Chinese Li subjects who cleared HCV spontaneously than those who were chronically infected (P = .036 and P = .024, respectively), which were consistent with our previous report regarding the Chinese Han population. Multivariate logistic regression analysis showed that DQB1*03:01 (odds ratio = 3.899, P = .017), but not DRB1*11:01, associated with HCV spontaneous clearance, independent of age, sex, and IFNL3 genotype. Because DQB1*03:01 and DRB1*11:01 were tightly linked because of linkage disequilibrium, our results clearly supported the associations of these two alleles with HCV spontaneous clearance in Chinese Li as well as Han ethnicity. |
| Databáze: | OpenAIRE |
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