Amelioration of delayed-type hypersensitivity responses by IL-27 administration
| Autor: | Yohei Shimanoe, Yoshiyuki Miyazaki, Seng Wang, Hiroki Yoshida |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
CD4-Positive T-Lymphocytes
medicine.medical_treatment Biophysics Inflammation Biochemistry Mice In vivo medicine Animals Receptors Cytokine Molecular Biology Immunosuppression Therapy business.industry Interleukin-17 Interleukin Immunosuppression Cell Biology Receptors Interleukin medicine.disease Mice Mutant Strains Recombinant Proteins Interleukin-10 Interleukin 10 Disease Models Animal Cytokine Immunology Dermatitis Allergic Contact Mutation Immune disorder medicine.symptom business Cytokine receptor |
| Zdroj: | Biochemical and biophysical research communications. 373(3) |
| ISSN: | 1090-2104 |
| Popis: | Interleukin (IL-) 27 is a member of the IL-12 cytokine family. Although recent analyses of WSX-1 (IL-27 receptor alpha chain)-deficient mice as well as in vitro studies using recombinant IL-27 revealed the immunosuppressive function of IL-27, in vivo role and therapeutic potential of IL-27 remain poorly elucidated. Here we investigated the effect of IL-27 administration on delayed-type hypersensitivity (DTH). While WSX-1-deficient mice showed higher DTH responses as shown by the degree of footpad swelling, administration of IL-27 significantly ameliorated the footpad swelling. Since the activation status of the draining lymph node cells were not affected by IL-27 deficiency, it was suggested that IL-27 affected the effector phase of the response. These results collectively indicate that IL-27 has a suppressive effect on activated T cells in the experimental model and also has a therapeutic potential for some diseases caused by immune disorder. |
| Databáze: | OpenAIRE |
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