Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in Vitro Anticancer Activity
| Autor: | SangGuan You, Myoung Lae Cho, Boo-Yong Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Antineoplastic Agents Undaria Undaria pinnatifida Molecular conformation Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Sulfation lcsh:Organic chemistry Polysaccharides Cell Line Tumor Drug Discovery Spectroscopy Fourier Transform Infrared Molecule Humans Physical and Theoretical Chemistry Sulfate oversulfation Cell Proliferation chemistry.chemical_classification Fucoidan Sulfates Communication Organic Chemistry Polymer fucoidans In vitro Molecular Weight anticancer activity chemistry molecular conformation Chemistry (miscellaneous) Cell culture Molecular Medicine |
| Zdroj: | Molecules Molecules, Vol 16, Iss 1, Pp 291-297 (2010) |
| ISSN: | 1420-3049 |
| Popis: | Low and high molecular weight fucoidans (F5-30K and F>30K) were chemically modified through the addition of sulfate groups, and the effect of oversulfation on the in vitro anticancer activity was investigated. After the addition of sulfate groups, a considerable increase of 35.5 to 56.8% was observed in the sulfate content of the F5-30K fraction, while the sulfate content of the F>30K fraction increased to a lesser extent (from 31.7 to 41.2%). Significant differences in anticancer activity were observed between the oversulfated F5–30K and F>30K fractions, with activities of 37.3–68.0% and 20.6–35.8%, respectively. This variation in the anticancer activity of oversulfated fucoidan derivatives was likely due to differences in their sulfate content. The results suggest that the molecular conformation of these molecules is closely related to the extent of sulfation in the fucan backbones and that the sulfates are preferably substituted when the fucoidan polymers are in a loose molecular conformation. |
| Databáze: | OpenAIRE |
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