A retrospective study of pyogenic liver abscess focusing on Klebsiella pneumoniae as a primary pathogen in China from 1994 to 2015
| Autor: | Leimin Sun, Weili Liu, Jianmin Si, Yun Qian, Jiancang Zhou, Huarong Chen, Jiaguo Wu, Sanchuan Lai, Daoyang Zhou, Jun Yu, Xingkang He, Chi Chun Wong |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
China medicine.medical_specialty Klebsiella pneumoniae History 21st Century Gastroenterology Article Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine stomatognathic system Internal medicine Diabetes mellitus Escherichia coli Humans Medicine 030212 general & internal medicine Pathogen Escherichia coli Infections Aged Retrospective Studies Pyogenic liver abscess Multidisciplinary biology business.industry Incidence (epidemiology) Fatty liver Retrospective cohort study Odds ratio History 20th Century Middle Aged respiratory system equipment and supplies medicine.disease biology.organism_classification Klebsiella Infections Liver Abscess Pyogenic Female lipids (amino acids peptides and proteins) 030211 gastroenterology & hepatology business |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep38587 |
| Popis: | Pyogenic liver abscess (PLA) is a common intra-abdominal infection in adults. In this study, we aim to explore demographic and clinical characteristics of PLA focusing on Klebsiella pneumoniae (K. pneumoniae) induced PLA (KP-PLA) in mainland China. A retrospective review of medical records from all patients with KP-PLA admitted to a tertiary teaching hospital over a 21-year period (1994–2015) was performed. Among 296 PLA cases with confirmed culture-positive data, K. pneumoniae was revealed as the predominant pathogen (n = 189, 63.9%), followed by Escherichia coli (n = 39, 13.2%). Strikingly, KP-PLA patients had a higher incidence of metabolic disorders, such as diabetes mellitus (49.7% vs. 36.4%, P = 0.027; odds ratio (OR): 1.725; 95% confidence interval (CI): 1.061–2.805), hypertension (38.1% vs. 19.6%, P = 0.001; OR: 2.520; 95% CI: 1.439–4.413), and fatty liver (32.3% vs. 14.0%, P = 0.001; OR: 2.923; 95% CI: 1.564–5.462) than those with non-K. pneumoniae induced PLA (non-KP-PLA). Moreover, patients with KP-PLA had higher susceptibility to septic metastatic infection at distant sites compared to those with non-KP-PLA (10.6% vs. 3.7%, p = 0.038). Our results indicate that K. pneumoniae is the predominant pathogen of PLA in mainland China. KP-PLA is frequently diagnosed in patients with metabolic diseases and has a higher risk for septic metastatic infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|