Multicenter retrospective analysis of clinicopathological features and prognosis of oral tongue squamous cell carcinoma in adolescent and young adult patients
| Autor: | Tetsuya Yoda, Maiko Tsuchiya, Yasuyuki Michi, Tohru Ikeda, Tomofumi Naruse, Hiroyuki Harada, Misaki Yokokawa, Masahiro Umeda, Eri Shibata, Takeshi Kuroshima, Hirofumi Tomioka, Kohei Okuyama, Hiroaki Shimamoto, Souichi Yanamoto |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent disease-free survival Tongue squamous cell carcinoma medicine.medical_treatment overall survival Observational Study Therapeutics Logistic regression Young Adult Internal medicine Retrospective analysis Humans Medicine elective neck dissection Young adult Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Medical record Significant difference therapeutic neck dissection Neck dissection General Medicine humanities Tongue Neoplasms oral tongue squamous cell carcinoma Elective Surgical Procedures Case-Control Studies Carcinoma Squamous Cell Neck Dissection Clinicopathological features Female business adolescents and young adults Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | The aim of this study is to report the differences in clinicopathological features of oral tongue squamous cell carcinoma (OTSCC) and survival between adolescent and young adult (AYA) patients and elderly patients and to find the prognosticators. The medical records of 101 AYA patients and 175 control patients with OTSCC who underwent surgery were reviewed. Variables related to prognosis and their clinicopathological associations were analyzed. The 5-year overall survival (5y-OS) rates of AYA and control patients with stage I and II OTSCC were 94.4% and 89.6% (P = .353), respectively, and their 5-year disease-free survival (5y-DFS) rates were 82.0% and 76.6%, respectively (P = .476). The 5y-OS rates of patients with stages III and IV OTSCC were 83.3% and 66.7% (P = .333), respectively, and their 5y-DFS rates were 75.0% and 57.1% (P = .335), respectively. Logistic regression analysis revealed that there was no significant clinicopathological difference in AYA and control group. Furthermore, there was no significant difference in 5y-OS rates between patients who underwent elective neck dissection (END) and those who underwent therapeutic neck dissection (TND) in both group (P = 0.717 and 0.688). Overall, the present study revealed the clinicopathological features and prognosis of OTSCC were similar in AYA patients and elderly patients. Moreover, as there was no significant difference in OS between patients who underwent END and those who underwent TND in AYA and control groups, our results suggest that the indication for END in AYA patients with clinical N0 OTSCC is similar to that for elderly patients. |
| Databáze: | OpenAIRE |
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