DNA methylation from germline cells in veterans with PTSD
| Autor: | Sarah McLeay, Dagmar Bruenig, John N. Gibson, Miriam Dwyer, Wendy Harvey, Darrell H. G. Crawford, Divya Mehta, C. R. Strakosch, Robyn O'Sullivan, Charles P. Morris, Rachel Thomson, Bruce R. Lawford, Ross McD. Young, David Colquhoun, John M. Gibson, Joanne Voisey, Madeline Romaniuk, Graham Cooksley, Elise S. Pelzer |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Germline Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine Intergenic region Transgenerational epigenetics Humans Medicine Gene Biological Psychiatry Aged Veterans Genetics Combat Disorders business.industry Methylation DNA Methylation Middle Aged Spermatozoa Sperm 030227 psychiatry Psychiatry and Mental health CpG site DNA methylation CpG Islands business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Psychiatric Research. 116:42-50 |
| ISSN: | 0022-3956 |
| Popis: | In this study we investigated genome-wide sperm DNA methylation patterns in trauma-exposed Vietnam veterans. At the genome-wide level, we identified 3 CpG sites associated with PTSD in sperm including two intergenic and one CpG within the CCDC88C gene. Of those associated with PTSD in sperm at a nominal level, 1868 CpGs were also associated with PTSD in peripheral blood (5.6% overlap) including the RORA, CRHR1 and DOCK2 genes that have been previously implicated in PTSD. A total of 10 CpG sites were significantly associated with a reported history of a diagnosed mental health condition in children and reached genome-wide significance. CpGs associated with a history of a reported mental health condition in children were also enriched (90% of tested genes) for genes previously reported to be resistant to demethylation, making them strong candidates for transgenerational inheritance. In conclusion, our findings identify a unique sperm-specific DNA methylation pattern that is associated with PTSD. |
| Databáze: | OpenAIRE |
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