Intermolecular Hydroaminoalkylation of Alkynes
| Autor: | Malte Fischer, Marc Schmidtmann, Hermann Thye, Dennis Geik, Tobias Kaper, Sven Doye, Ruediger Beckhaus |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Allylic rearrangement 010405 organic chemistry Alkene Communication Organic Chemistry Intermolecular force amines Alkyne chemistry.chemical_element General Chemistry 010402 general chemistry alkynes 01 natural sciences Communications Catalysis C−H activation 0104 chemical sciences chemistry hydroaminoalkylation Polymer chemistry titanium Titanium |
| Zdroj: | Chemistry (Weinheim an Der Bergstrasse, Germany) |
| ISSN: | 1521-3765 |
| Popis: | Intermolecular hydroaminoalkylation reactions of alkynes with secondary amines, which selectively give access to allylic amines with E configuration of the alkene unit, are achieved in the presence of titanium catalysts. Successful reactions of symmetrically substituted diaryl‐ and dialkylalkynes as well as a terminal alkyne take place with N‐benzylanilines, N‐alkylanilines, and N‐alkylbenzylamines. Allylic amines are directly formed from secondary amines and alkynes in the presence of highly active titanium catalysts. The corresponding hydroaminoalkylation reactions, which take place by C−H bond activation at sp3‐centers in the α‐position to a nitrogen atom, can be achieved with internal and terminal alkynes, and best results are obtained with N‐benzylaniline derivatives. |
| Databáze: | OpenAIRE |
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