Diagnostic value of antineutrophil cytoplasmic antibodies in children with bronchiolitis obliterans
| Autor: | Shang-zhi Wu, Jingbin Chen, Xiao-an Pan, Shaolin Yang, Wenkuan Liu, Yong Cai, Yu-neng Lin, Na Xie, Dehui Chen, Zifeng Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry Bronchiolitis obliterans medicine.disease Gastroenterology respiratory tract diseases Serology 03 medical and health sciences Pneumonia 0302 clinical medicine 030228 respiratory system Serum biomarkers Internal medicine Immunology medicine Original Article cardiovascular diseases 030212 general & internal medicine Acute pneumonia business Hospital stay Anti-neutrophil cytoplasmic antibody |
| Popis: | BACKGROUND Diagnosis of childhood bronchiolitis obliterans (BO) is difficult owing to non-specific clinical presentations and limited investigational options. There is a lack in established serum biomarkers for BO. While the diagnostic value of antineutrophil cytoplasmic antibodies (ANCAs) has been discussed, little is known about this in BO. We aimed to investigate the serological profiles of ANCAs against myeloperoxidase (MPO-ANCA) and proteinase-3 (PR3-ANCA) in BO and acute pneumonia. METHODS In this study, 42 BO children (BO group) and 43 with mild acute pneumonia (pneumonia group) were included, based on rigorous diagnostic criteria and additional constraints for minimizing selection bias. Serum MPO-ANCA and PR3-ANCA levels were measured on the first (baseline) and the last day of hospitalization (on discharge) by enzyme linked immunosorbent assay. RESULTS Although the BO children had a longer hospital stay, the overall rate of positivity (≥180 AAU/mL) and median serum level of MPO-ANCA were higher in the BO group compared with the pneumonia group, either at baseline (69.1% vs. 9.3%, 292.00 vs. 104.75 AAU/mL, both P |
| Databáze: | OpenAIRE |
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