Identification and comparison of insulin pharmacokinetics injected with a new 4‐mm needle vs 6‐ and 8‐mm needles accounting for endogenous insulin and C‐peptide secretion kinetics in non‐diabetic adult males
| Autor: | Shusaku Tozaka, Takahisa Hirose, Hirotaka Watada, Takeshi Ogihara, Sami Kanderian |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Bioequivalence Body fat percentage chemistry.chemical_compound Pharmacokinetics Diabetes mellitus Internal medicine Internal Medicine medicine Insulin lispro Insulin C-peptide business.industry Area under the curve General Medicine Articles medicine.disease Endocrinology Clinical Science and Care chemistry Needle length Original Article business medicine.drug |
| Zdroj: | Journal of Diabetes Investigation |
| ISSN: | 2040-1124 2040-1116 |
| Popis: | Aims/Introduction Many patients with diabetes now use 5-, 6- or 8-mm needles for insulin injection. However, it is unclear whether needle length, particularly for shorter needles, affects the pharmacokinetic properties of insulin. Materials and Methods This was a three-way, randomized, cross-over, single-center study involving 12 healthy Japanese adult males (age 27.4 ± 4.14 years; weight 64.2 ± 5.2 kg; body fat percentage 18.2 ± 1.5%). Participants received a subcutaneous (abdomen) dose of insulin lispro (1.5 U for participants weighing 55 to |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |