Molecular surveillance of brazilian meningococcal isolates serogroup c in the pre and post-men-c-vaccination period: Emergence of ST-3780
| Autor: | Nathércia Elena Chança Franco, Aline Carvalho de Azevedo, Marcella Reis de Carvalho Rocha, Maria Celeste Torres, Ivano de Filippis, Claudia Ferreira de Andrade |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) 030106 microbiology Meningococcal Vaccines Neisseria meningitidis Serogroup C Biology Serogroup Meningococcal disease medicine.disease_cause Microbiology 03 medical and health sciences Conjugate vaccine Genetics medicine Humans Typing Allele Molecular Biology Phylogeny Ecology Evolution Behavior and Systematics Antigens Bacterial Neisseria meningitidis Genetic Variation medicine.disease Antibodies Bacterial Virology Meningococcal Infections Vaccination 030104 developmental biology Infectious Diseases Genetic marker Population Surveillance Multilocus sequence typing Brazil Multilocus Sequence Typing |
| Zdroj: | Infection, Genetics and Evolution. 78:104079 |
| ISSN: | 1567-1348 |
| Popis: | Meningococcal disease is a devastating infection caused by Neisseria meningitidis (meningococcus), and it is classified into serogroups according to its polysaccharide capsule composition. In Brazil, serogroup C is the most frequently responsible for the majority of cases, representing a serious public health challenge. In 2010, the meningococcal serogroup C conjugate vaccine was included in the calendar of the National Immunization Program. We have evaluated 163 meningococcal isolates collected during the pre (2006-2010) and post (2011-2016) vaccination periods. Epidemiological data were determined through Multilocus Sequence Typing (MLST) analysis, vaccine antigens and Bexsero Antigen Sequence Typing (BAST) variant. Clonal complex 103 remains the most prevalent in the country with a high number of serogroup C strains to which CC103 is directly associated. A total of 42 different ST were found. The two most prevalent ST were ST-3780 (CC103) with 38 strains and ST-10781, which was not associated with a CC with nine strains. Allele abcZ-276 was reported among 98% of the strains analyzed and it was not found among other CC103 strains worldwide, makes this allele an important genetic marker for a specific new clone only assigned to Brazilian serogroup C strains, ST-3780. FHbp-25 and NHBA-42 peptides were the most prevalent among isolates in both periods studied. BAST-824 and BAST-3073 have been expressed only in CC103 over the studied years, however, it was not possible to associate a BAST variant to a specific CC. Serogroup C phenotype [P1.22,14-6,36-2: F3-9: ST-3780 (CC103)] was the most prevalent according to the antigenic profiles of circulating strains in Brazil (2007-2016). Our study suggests that CC103 is still a major hypervirulent CC circulating in Brazil and ST-3780 is currently spreading all over the country even after the introduction of MenC in 2010. |
| Databáze: | OpenAIRE |
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