Side-effects of lithium at lower therapeutic levels: the significance of thirst
| Autor: | R. P. Hullin, J. R. King, P. R. Aylard |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
Vasopressin Bipolar Disorder Lithium (medication) medicine.medical_treatment Drinking Renal function Lithium Thirst Kidney Concentrating Ability Polyuria Internal medicine medicine Humans Bipolar disorder Antipsychotic Applied Psychology Renal water absorption business.industry medicine.disease Psychiatry and Mental health Endocrinology medicine.symptom business Glomerular Filtration Rate medicine.drug |
| Zdroj: | Psychological Medicine. 15:355-361 |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/s0033291700023643 |
| Popis: | SynopsisThe prevalence of thirst, subjective polyuria and related side-effects was investigated in 87 patients attending a lithium clinic and in a group of 52 controls. Thirst was surprisingly common, occurring in 67% of patients, in spite of the fact that they had been maintained on relatively low levels of lithium, and was due principally to the lithium rather than to other psychotropic drugs. Urine flow and impaired renal water absorption correlated with the serum lithium level and the length of treatment in the patients, despite the fact that few were clinically polyuric. The pattern of the results confirms previous suggestions that lithium may stimulate the thirst mechanism directly as well as via an increased renal resistance to vasopressin. The possible implications in terms of clinical response are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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