Aspirin resistance predicts unfavorable functional outcome in acute ischemic stroke patients
| Autor: | Ying He, Si-Bei Ji, Bin Yuan, Yan-nan Fan, Ting-ting Xi, Lin-Lin Su, Qiu-Ju Hua, Chao-Wei Wang, Yan-Xia Liu |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Drug Resistance 030204 cardiovascular system & hematology Severity of Illness Index Brain Ischemia 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans In patient Prospective Studies ASPIRIN RESISTANCE Acute ischemic stroke Aged Nihss score Aspirin business.industry General Neuroscience Middle Aged Prognosis Stroke Aspirin therapy Cohort Ischemic stroke Female business 030217 neurology & neurosurgery Platelet Aggregation Inhibitors medicine.drug Follow-Up Studies |
| Zdroj: | Brain research bulletin. 142 |
| ISSN: | 1873-2747 |
| Popis: | To investigate the prognostic value of aspirin reaction units (ARU) in a 3-month follow-up study in a cohort of Chinese patients with first-ever ischemic stroke.Prospective single-center survey of acute ischemic stroke patients receiving aspirin therapy. Two hundred and seventy-five Chinese patients with first-ever ischemic stroke who previously received aspirin therapy were enrolled. ARU was measured using the VerifyNow system. A cutoff of 550 ARU was used to determine the presence of aspirin resistance (AR).Median age at study entry was 67 years (IQR: 59-75) and 142(51.6%) were male. A total of 52 of 275 enrolled patients (18.9%) were AR. Median regression estimated a statistically significant increase in NIHSS score of 0.033 point for every 1-point increase in ARU (95% CI, 0.024 to 0.068; P 0.001). The unfavorable outcomes distribution across the ARU quartiles ranged between 11.8% (first quartile) to 64.8% (fourth quartile). After adjusting for other established risk factors, in multivariate models comparing the third and fourth quartiles against the first quartile of the ARU, levels of ARU were associated with unfavorable outcome, and the adjusted risk of unfavorable outcome increased by 145% (OR = 2.45 [95% CI 1.46-3.87], P = 0.011) and 317% (4.17[2.76-6.15], P 0.001), respectively. Similarly, the adjusted risk of mortality increased by 215% (OR = 3.15 [95% CI 1.98-4.73], P = 0.008) and 429% (5.29[4.02-8.17], P 0.001), respectively.The results suggest that AR is a meaningful and independent marker to predict short-term functional outcome in patients with ischemic stroke. |
| Databáze: | OpenAIRE |
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