Upfront molecular profiling of pancreatic cancer patients – An idea whose time has come
| Autor: | Irina M. Cazacu, Sinchita Roy-Chowdhuri, Manoop S. Bhutani, Anirban Maitra, Michael J. Pishvaian |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Disease Off-label use 03 medical and health sciences 0302 clinical medicine Pancreatic cancer medicine Humans Profiling (information science) Precision Medicine Intensive care medicine Hepatology business.industry Gene Expression Profiling Gastroenterology Middle Aged medicine.disease Precision medicine Pancreatic Neoplasms 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Personalized medicine business Carcinoma Pancreatic Ductal |
| Zdroj: | Pancreatology. 20:391-393 |
| ISSN: | 1424-3903 |
| Popis: | Pancreatic cancer patients have not benefited from survival improvements brought about by personalized medicine in other malignancies. Even though this is the era of precision medicine, unfortunately most clinicians in practice either do not embrace or are unaware of the concept of molecular profiling for pancreatic cancer patients. Improving the grim prognosis of this challenging disease requires a paradigm shift. To exploit all potential therapeutic options in this lethal disease, molecular profiling should be performed ideally at the moment of diagnosis to identify potentially trial-eligible tumoral mutations or support off label use of an agent approved for another indication. This perspective article aims to increase awareness of the importance of upfront molecular profiling for pancreatic cancer patients. |
| Databáze: | OpenAIRE |
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