Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition
| Autor: | Christian Meyer, Karen F. Berman, Ryan Kelly, Yan Zhang, Jan Willem van der Veen, Daniel R. Weinberger, Jun Shen, Stefano Marenco, Dwight Dickinson |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Elementary cognitive task Aging Magnetic Resonance Spectroscopy Adolescent behavioral disciplines and activities Gyrus Cinguli Article White matter 03 medical and health sciences Young Adult 0302 clinical medicine Atrophy Cognition Wisconsin Card Sorting Test Internal medicine medicine Humans Neurochemistry Cognitive Dysfunction Effects of sleep deprivation on cognitive performance Anterior cingulate cortex gamma-Aminobutyric Acid Pharmacology business.industry Middle Aged medicine.disease Psychiatry and Mental health 030104 developmental biology Endocrinology medicine.anatomical_structure nervous system GABAergic Female business 030217 neurology & neurosurgery |
| Zdroj: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 43(11) |
| ISSN: | 1740-634X |
| Popis: | GABAergic mechanisms have been shown to contribute to cognitive aging in animal models, but there is currently limited in vivo evidence to support this relationship in humans. It is also unclear whether aging is associated with changes in GABA levels measured with proton magnetic resonance spectroscopy (MRS). Spectral-editing MRS at 3 T was used to measure GABA in the dorsal anterior cingulate cortex (dACC) for a large sample of healthy volunteers (N = 229) aged 18–55. In a subset of 171 participants, age effects on several cognitive tasks were studied. We formally tested whether the MRS measures mediated the relationship between age and cognition. Robust associations of age with performance were found for the Wisconsin Card Sorting Test ([WCST], p |
| Databáze: | OpenAIRE |
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