Epidemiología genética sobre las teorías causales y la patogénesis de la diabetes mellitus tipo 2
| Autor: | Diana García-Cruz, Nemesio Villa-Ruano, Carlos J Castro-Juárez, Sergio Alberto Ramirez-Garcia |
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| Rok vydání: | 2017 |
| Předmět: |
Aging
medicine.medical_specialty Genotype medicine.medical_treatment 030209 endocrinology & metabolism Disease Biology 03 medical and health sciences 0302 clinical medicine Insulin resistance Risk Factors Diabetes mellitus medicine Humans 030212 general & internal medicine Genetics Public health Insulin Inheritance (genetic algorithm) General Medicine medicine.disease Causality Oxidative Stress Phenotype Diabetes Mellitus Type 2 Food Etiology Gene-Environment Interaction |
| Zdroj: | Gaceta de M�xico. 153 |
| ISSN: | 0016-3813 |
| Popis: | Diabetes mellitus type 2 (DM2) is a worldwide public health problem. The etiology of the disease is multifactorial and is characterized by great heterogeneity of metabolic disorders. The most common are the insufficient production of insulin, insulin resistance and impaired incretin system. The specialist must understand the multi-causal nature of DM2 in the post-genomic era. This nature is determined by the additive effect of genes and environment, so there is no simple genetic epidemiological model to explain the inheritance pattern. Hence the need to establish the proportion of disease that is determined by genes and the contribution of environmental factors, the combination of which regulates the threshold or tolerance level for diabetes development. Given this complexity in DM2 in this work are discussed the various existing theories of causality of this disease, which will permit us to understand the interaction between the environment and the human genome, and also to know how risk factors or predisposition to this disease influence, laying the grounds that delimit environment interaction with the genome. |
| Databáze: | OpenAIRE |
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