A 2D nanotheranostic platform based on graphene oxide and phase-change materials for bimodal CT/MR imaging, NIR-activated drug release, and synergistic thermo-chemotherapy

Autor: Mehri, Mirrahimi, Zahra, Alamzadeh, Jaber, Beik, Abolfazl, Sarikhani, Mahdie, Mousavi, Rasoul, Irajirad, Tahereh, Khani, Elnaz S, Davani, Ali, Farashahi, Tahereh Shakerian, Ardakani, Jeff W M, Bulte, Habib, Ghaznavi, Ali, Shakeri-Zadeh
Rok vydání: 2022
Předmět:
Zdroj: Nanotheranostics. 6:350-364
ISSN: 2206-7418
Popis: Recent years have seen considerable progress in the development of nanomedicine by the advent of 2D nanomaterials serving as ideal platforms to integrate multiple theranostic functions. We synthesized multifunctional stimuli-responsive 2D-based smart nanocomposites (NCs), comprising gold nanoparticles (AuNPs) and superparamagnetic iron oxides (SPIOs) scaffolded within graphene oxide (GO) nanosheets, coated with doxorubicin (DOX)-loaded 1-tetradecanol (TD), and further modified with an alginate (Alg) polymer. TD is a phase-change material (PCM) that confines DOX molecules to the GO surface and melts when the temperature exceeds its melting point (
Databáze: OpenAIRE