Interrelation of polymorphic allelic rs619203 option of a gene receptor of a tirozinkinaza (ROS1) with cardiovascular diseases at patients with an ischemic stroke
| Autor: | S. V. Prokopenko, V. N Chernov, I. M. Platunova, A. A. Chernova, V. A. Shulman, S. Yu Nikulina, D. A. Nikulin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
arterial hypertension lcsh:Diseases of the circulatory (Cardiovascular) system heart failure Single-nucleotide polymorphism medicine.disease_cause lcsh:Diseases of the endocrine glands. Clinical endocrinology Diabetes mellitus Internal medicine Genotype Heredity medicine ROS1 ischemic stroke Allele coronary heart disease lcsh:RC648-665 business.industry medicine.disease medicine.anatomical_structure allelic rs619203 option of a gene of ros1 lcsh:RC666-701 Heart failure atrial fibril-lation diabetes mellitus business Artery |
| Zdroj: | КардиоСоматика, Vol 6, Iss 2, Pp 6-11 (2015) |
| ISSN: | 2658-5707 2221-7185 |
| Popis: | Studying of interrelation of polymorphic allelic rs619203 option of a gene of ROS1 with cardiovascular diseases at persons with the ischemic stroke is carried out. For the purpose of studying of a role of single nucleotide polymorphism of rs619203 of a gene of ROS1 in development of strokes of a genotiping 124 patients with ischemic stroke and cardiovascular pathology and 475 people of group of control. Persons with ischemic stroke are divided into subgroups according to a sex, the affected artery, the diseases which are available cardiovascular, risk factors, such as the raised body weight index, the burdened heredity on a stroke, smoking. For verification of the diagnosis by all patient standard neurologic examination, a computer tomography of a brain, and also the retrospective analysis of results of the previous inspections (are conducted at their existence), for definition of a genotype on ROS1 gene ONP - molecular and genetic research DNA. The received results showed prevalence of a homozygous genotype of GG on extended allel among patients from ischemic stroke having the arterial hypertension in comparison with control group. Thus, the genotype of GG has conditionally protective effect concerning development of ischemic stroke in persons with arterial hypertension. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|