Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue
| Autor: | Go Suzuki, Naomi Oka, Keiji Mitani, Yasuo Mukai, Wataru Yamadera, Kazuya Shimada, Kazuhiro Kondo, Masashi Nibuya, Masayuki Iwashita, Nobuyuki Kobayashi, Ryo Aoki, Mayumi Takahashi, Kazuhiko Nakayama, Hiroshi Ito, Hirohiko Kuratsune, Shinichi Tokuno, Masaaki Tanichi |
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| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Adult Male Herpesvirus 6 Human viruses Biophysics Herpesvirus 7 Human Major depressive disorder Bioinformatics Sensitivity and Specificity Biochemistry Diagnosis Differential HHV-6 03 medical and health sciences HHV-7 0302 clinical medicine Quality of life Chronic fatigue syndrome medicine Humans Risk factor Saliva Pathological Molecular Biology Fatigue Fatigue Syndrome Chronic biology business.industry Reproducibility of Results virus diseases Cell Biology Viral Load medicine.disease biology.organism_classification Obstructive sleep apnea Obstructive sleep apnea syndrome 030104 developmental biology Military Personnel 030220 oncology & carcinogenesis Biomarker (medicine) Human herpesvirus 6 business Biomarkers |
| Zdroj: | Biochemical and Biophysical Research Communications. (1):424-430 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2016.07.010 |
| Popis: | Fatigue reduces productivity and is a risk factor for lifestyle diseases and mental disorders. Everyone experiences physiological fatigue and recovers with rest. Pathological fatigue, however, greatly reduces quality of life and requires therapeutic interventions. It is therefore necessary to distinguish between the two but there has been no biomarker for this. We report on the measurement of salivary human herpesvirus (HHV-) 6 and HHV-7 as biomarkers for quantifying physiological fatigue. They increased with military training and work and rapidly decreased with rest. Our results suggested that macrophage activation and differentiation were necessary for virus reactivation. However, HHV-6 and HHV-7 did not increase in obstructive sleep apnea syndrome (OSAS), chronic fatigue syndrome (CFS) and major depressive disorder (MDD), which are thought to cause pathological fatigue. Thus, HHV-6 and HHV-7 would be useful biomarkers for distinguishing between physiological and pathological fatigue. Our findings suggest a fundamentally new approach to evaluating fatigue and preventing fatigue-related diseases. |
| Databáze: | OpenAIRE |
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