Cortisol and Cortisone in Early Childhood in Very-Low-Birthweight Infants and Term-Born Infants
| Autor: | Jos W. R. Twisk, Anneke Cranendonk, Mirjam M. van Weissenbruch, Miranda de Jong |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism medicine.medical_treatment chemistry.chemical_compound Endocrinology Standard care medicine Humans Infant Very Low Birth Weight Early childhood Appropriate for gestational age Cholesterol business.industry Insulin Infant Newborn medicine.disease Cortisone chemistry Case-Control Studies Pediatrics Perinatology and Child Health Female Metabolic syndrome business Serum cortisol medicine.drug |
| Zdroj: | Hormone Research in Paediatrics. 93:453-459 |
| ISSN: | 1663-2826 1663-2818 |
| DOI: | 10.1159/000512784 |
| Popis: | Introduction: Besides programming of the hypothalamic-pituitary-adrenal (HPA) axis, changes in the activity of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) could contribute to the later metabolic and cardiovascular consequences of preterm birth. Objective: We compared serum cortisol, cortisone, and cortisol/cortisone ratio in early childhood in very-low-birthweight (VLBW) infants and term appropriate for gestational age (AGA) born infants. Methods: We included 41 VLBW infants, participating in the randomized controlled Neonatal Insulin Replacement Therapy in Europe trial, and 64 term AGA-born infants. Cortisol and cortisone were measured in blood samples taken at 6 months and 2 years corrected age (VLBW children) and at 3 months and 1 and 2 years (term children). At 2 years of (corrected) age (HDL) cholesterol, triglycerides, glucose, and insulin were also measured. Results: During the first 2 years of life, cortisol/cortisone ratio is higher in VLBW children compared to term children. In the total group of children, cortisol/cortisone ratio is positively related to triglycerides at 2 years of (corrected) age. In VLBW children, over the first 2 years of life both cortisol and cortisone are higher in the early-insulin group compared to the standard care group. Conclusions: In VLBW infants, lower 11β-HSD2 activity probably contributes to the long-term metabolic and cardiovascular risks. In VLBW infants, early insulin treatment could affect programming of the HPA axis, resulting in higher cortisol and cortisone levels during early childhood. |
| Databáze: | OpenAIRE |
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