Treatment of Dendropanax morbifera leaves extract improves diabetic phenotype and inhibits diabetes induced retinal degeneration in db/db mice
| Autor: | Jun Kim, Jae-Hyuk Byun, Se-Young Choung, Myeong-Gang Heo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Retinal degeneration medicine.medical_specialty medicine.medical_treatment Dendropanax morbifera Medicine (miscellaneous) Adipose tissue 03 medical and health sciences 0302 clinical medicine Insulin resistance Diabetes mellitus Internal medicine Type 2 diabetes mellitus medicine Glucose homeostasis TX341-641 Db/db mice Glucose transporter Nutrition and Dietetics AMP-activated protein kinase Nutrition. Foods and food supply business.industry Insulin Pancreatic islets medicine.disease Metformin 030104 developmental biology Endocrinology medicine.anatomical_structure 030220 oncology & carcinogenesis business Food Science medicine.drug |
| Zdroj: | Journal of Functional Foods, Vol 46, Iss, Pp 136-146 (2018) |
| ISSN: | 1756-4646 |
| Popis: | To appraise the effects and involved mechanism of Dendropanax morbifera leaves extract (DLE) on diabetes and retinal degeneration, in this study, male C57BLKS/J-m+/db and five groups of db/db mice were treated with 0.5% CMC or metformin or three doses of DLE for 6 weeks. Administration of DLE stimulated AMP-activated protein kinase in the liver, skeletal muscle and adipose tissue, leading to the improvement of gene and protein expression related with insulin resistance and glucose homeostasis in db/db mice. Morphological changes and insulin depletion of pancreatic islets were also attenuated by treatment of DLE. Moreover, DLE treatment prevented the deterioration of retina by regulating not only the gene expression related with apoptosis and neovascularization, but also the level of activator protein-1 in retina. Therefore, DLE improves diabetic phenotype and retinal degeneration, suggesting that DLE could be a prospective agent for preventing diabetes and related eye complication. |
| Databáze: | OpenAIRE |
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