Identification of bovine papillomavirus type 1 and 2 from bovine anogenital fibropapillomas
| Autor: | Nanako Yamashita-Kawanishi, Masano Tsuzuki, Zhu Wei, Hidekatsu Shimakura, Mun Keong Kok, Takeshi Haga, Dai Ishiyama, Jianbao Dong, Kazuyuki Uchida, James K. Chambers |
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| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Clinical Pathology 040301 veterinary sciences viruses bovine papillomavirus Cattle Diseases fibropapilloma Biology 0403 veterinary science 03 medical and health sciences Antigen medicine Animals Neoplasm RNA Messenger Antigens Viral Pathogen Bovine papillomavirus 1 030304 developmental biology Bovine papillomavirus 0303 health sciences Papilloma Vulvar Neoplasms General Veterinary Early region Papillomavirus Infections 04 agricultural and veterinary sciences Anus Neoplasms Note biology.organism_classification medicine.disease cattle anogenital tumor Anal warts DNA Viral Immunohistochemistry Female |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.19-0017 |
| Popis: | Papillomavirus (PV) is a well-known pathogen associated with epithelial and mucosal neoplastic diseases. In contrast to human PVs, characterization of animal PVs from the aspect of anogenital neoplasm is still on a learning curve. In the present study, two vulval and one anal warts, histologically diagnosed as fibropapillomas, excised from dairy cattle were analyzed. PCR and sequencing revealed that bovine papillomavirus type 1 (BPV-1) and BPV-2 were detected from anal and vulval fibropapillomas, respectively. Immunohistochemistry detected PV antigen in a few differentiated keratinocytes of one vulval case. Reverse-transcriptase PCR detected the early region, but not the late region of BPV mRNA in all three cases. The present study will provide new insight into the relationship between BPV and anogenital papilloma in cattle. |
| Databáze: | OpenAIRE |
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