Sex dimorphism in the relation between early adiposity and cardiometabolic risk in adolescents
| Autor: | Trevor A. Mori, Chi Le Ha, Lawrence J Beilin, Carly E. Herbison, Rae-Chi Huang, Wendy H. Oddy, Sally A Burrows, Beth H. Hands |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Waist Adolescent Endocrinology Diabetes and Metabolism Birth weight Clinical Biochemistry Context (language use) Biochemistry Body Mass Index Endocrinology Pregnancy Risk Factors Diabetes mellitus Internal medicine medicine Birth Weight Humans Longitudinal Studies Obesity Sex Distribution Child Adiposity Metabolic Syndrome Sex Characteristics business.industry Incidence Biochemistry (medical) Infant Anthropometry medicine.disease Gestational diabetes Diabetes Mellitus Type 2 Cardiovascular Diseases Child Preschool Female business Body mass index Sex characteristics Follow-Up Studies |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 97(6) |
| ISSN: | 1945-7197 |
| Popis: | Birth weight and childhood adiposity are associated with subsequent cardiovascular risk.We investigated the associations between metabolic clusters in young adults with body fat distribution from early childhood, focusing on sex differences.A total of 1053 17 yr olds from an Australian birth cohort had measures of anthropometry, blood pressure, and fasting insulin, glucose, and lipids.Two-step cluster analysis identified 17 yr olds at high metabolic risk. The two risk groups were compared by sex with regard to birth weight and serial anthropometry, including skinfold thickness from nine time-points.The "high-risk" metabolic cluster at age 17 yr included 16% of males and 19% of females. Compared to the "low-risk" group, the high-risk cluster participants had greater waist circumference, triglycerides, insulin, and systolic blood pressure and lower high-density lipoprotein-cholesterol (all P0.0001). There was a significant birth weight by sex interaction upon the metabolic cluster outcome (P = 0.011). Compared to their low-risk counterparts, females in the high-risk cluster at 17 yr were heavier from birth (odds ratio, 1.8; 95% confidence interval, 1.0, 3.2) (P = 0.034), with consistently higher body mass index and skinfold thickness thereafter. In contrast, there was no statistical difference in birth weight between high- and low-risk males (odds ratio, 0.62; 95% confidence interval, 0.38, 1.02).These data show sexual dimorphism in effects of early life body mass index and fat distribution upon cardiometabolic risk factors. Females in a contemporary population are particularly prone to increased risk when born heavier. This has implications for targeted prevention of obesity and metabolic diseases with increasing maternal obesity and gestational diabetes. |
| Databáze: | OpenAIRE |
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