Inhibition of the Yersinia pestis Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis by α-Phenyl-Substituted Reverse Fosmidomycin Analogues
| Autor: | Beate Lungerich, Claudia Lienau, Haley Ball, Leandro A. Alves Avelar, Christoph T. Behrendt, Mosufa Zainab, Misgina Girma, Iswarduth Soojhawon, Thomas Kurz, Sarah Konzuch, Schroeder M. Noble, Honoria Riley, Robin D. Couch |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
biology organic chemicals General Chemical Engineering General Chemistry biology.organism_classification Phosphate Fosmidomycin Isoprenoid biosynthesis Chemistry chemistry.chemical_compound Enzyme chemistry Yersinia pestis Biochemistry parasitic diseases medicine QD1-999 medicine.drug |
| Zdroj: | ACS Omega, Vol 5, Iss 10, Pp 5170-5175 (2020) |
| ISSN: | 2470-1343 |
| Popis: | Fosmidomycin inhibits IspC (1-deoxy-d-xylulose 5-phosphate reductoisomerase), the first committed enzyme in the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis. The MEP pathway ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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