Recent conjugation strategies of small organic fluorophores and ligands for cancer-specific bioimaging
| Autor: | Hyun-Kyung Choi, Yonghwang Ha |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Aptamer Cancer Cellular receptor General Medicine Biology Toxicology medicine.disease Fluorescent imaging Combinatorial chemistry Small molecule Molecular Imaging 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Biochemistry 030220 oncology & carcinogenesis Neoplasms Nucleic acid medicine Animals Humans Molecular imaging Fluorescent Dyes |
| Zdroj: | Chemico-biological interactions. 248 |
| ISSN: | 1872-7786 |
| Popis: | Conjugation between various small fluorophores and specific ligands has become one of the main strategies for bioimaging in disease diagnosis, medicinal chemistry, immunology, and fluorescence-guided surgery, etc. Herein, we present our review of recent studies relating to molecular fluorescent imaging techniques for various cancers in cell-based and animal-based models. Various organic fluorophores, especially near-infrared (NIR) probes, have been employed with specific ligands. Types of ligands used were small molecules, peptides, antibodies, and aptamers; each has specific affinities for cellular receptor proteins, cancer-specific antigens, enzymes, and nucleic acids. This review can aid in the selection of cancer-specific ligands and fluorophores, and may inspire the further development of new conjugation strategies in various cellular and animal models. |
| Databáze: | OpenAIRE |
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