Associations Between Dietary Melatonin Intake and Total and Cause-Specific Mortality Among Japanese Adults in the Takayama Study
| Autor: | Chisato Nagata, Yusuke Maruyama, Shino Oba, Atsuhiko Hattori, Takahiro Uji, Sachi Koda, Keiko Wada, Michiyo Yamakawa, Sakiko Onuma, Yuma Nakashima |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Sociodemographic Factors Epidemiology Population Physiology Melatonin Eating Japan Cause of Death medicine Humans Prospective Studies Mortality education Aged education.field_of_study business.industry Mortality rate Hazard ratio Cause specific mortality Middle Aged Confidence interval Diet Quartile Female Sleep business hormones hormone substitutes and hormone antagonists medicine.drug Cohort study |
| Zdroj: | American Journal of Epidemiology. 190:2639-2646 |
| ISSN: | 1476-6256 0002-9262 |
| Popis: | Potential health benefits of melatonin have been suggested. Although melatonin is present in various foods, little is known about the health effects of dietary melatonin intake. We estimated habitual dietary melatonin intake and examined its association with total and cause-specific mortality in a population-based cohort study in Japan. Study subjects included 13,355 men and 15,724 women aged ≥35 years who responded to a self-administered questionnaire in 1992. Their diets were assessed via a food frequency questionnaire at baseline. The melatonin content in various foods on the questionnaire was measured to estimate melatonin intake. Mortality was ascertained during 16 years of follow-up (1992–2008). Hazard ratios (HRs) and 95% confidence intervals (CIs) for total and cause-specific mortality were calculated according to melatonin quartiles. A total of 5,339 deaths occurred during follow-up. Melatonin intake was significantly associated with decreased risks of total mortality, cardiovascular mortality, and noncancer, noncardiovascular mortality after controlling for covariates; HRs for the highest quartile of melatonin intake versus the lowest were 0.90 (95% CI: 0.82, 0.98; P for trend = 0.05), 0.85 (95% CI: 0.72, 0.99; P for trend = 0.10), and 0.77 (95% CI: 0.67, 0.90; P for trend = 0.003), respectively. The data suggest a potential benefit of dietary melatonin with regard to mortality rates. |
| Databáze: | OpenAIRE |
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