Rich-club reorganization of functional brain networks in acute mild traumatic brain injury with cognitive impairment
| Autor: | Fengfang, Li, Yin, Liu, Liyan, Lu, Song'an, Shang, Huiyou, Chen, Nasir Ahmad, Haidari, Peng, Wang, Xindao, Yin, Yu-Chen, Chen |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Quant Imaging Med Surg |
| ISSN: | 2223-4306 2223-4292 |
| DOI: | 10.21037/qims-21-915 |
| Popis: | BACKGROUND: Mild traumatic brain injury (mTBI) is typically characterized by temporally limited cognitive impairment and regarded as a brain connectome disorder. Recent findings have suggested that a higher level of organization named the “rich-club” may play a central role in enabling the integration of information and efficient communication across different systems of the brain. However, the alterations in rich-club organization and hub topology in mTBI and its relationship with cognitive impairment after mTBI have been scarcely elucidated. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 88 patients with mTBI and 85 matched healthy controls (HCs). Large-scale functional brain networks were established for each participant. Rich-club organizations and network properties were assessed and analyzed between groups. Finally, we analyzed the correlations between the cognitive performance and changes in rich-club organization and network properties. RESULTS: Both mTBI and HCs groups showed significant rich-club organization. Meanwhile, the rich-club organization was aberrant, with enhanced functional connectivity (FC) among rich-club nodes and peripheral regions in acute mTBI. In addition, significant differences in partial global and local network topological property measures were found between mTBI patients and HCs (P |
| Databáze: | OpenAIRE |
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