Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent brequinar sodium

Autor:	Douglas G. Batt, Elizabeth A. Jones, Donald J. P. Pinto, Pitts William J, Joseph J. Petraitis, Susan R. Sherk, Michael J. Orwat, Robert A. Copeland, Bruce D. Jaffee, Ronald L. Magolda, Randine L. Dowling, Tracy L. Gardner, Irina Cipora Jacobson, James W. Jetter
Rok vydání:	1998
Předmět:	Oxidoreductases Acting on CH-CH Group Donors Molecular model Stereochemistry Clinical Biochemistry Heteroatom Dihydroorotate Dehydrogenase Pharmaceutical Science Ring (chemistry) Biochemistry Chemical synthesis Structure-Activity Relationship Heterocyclic Compounds Drug Discovery Humans Enzyme Inhibitors Molecular Biology chemistry.chemical_classification biology Biphenyl Compounds Organic Chemistry Mixed lymphocyte reaction Enzyme chemistry Enzyme inhibitor Dihydroorotate dehydrogenase biology.protein Molecular Medicine Lymphocyte Culture Test Mixed Oxidoreductases Immunosuppressive Agents
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 8:307-312
ISSN:	0960-894X
Popis:	The structure-activity relationships of some tetracyclic heterocycles related to Brequinar were explored. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction are related to ring system, heteroatom placement, and pendant ring substitution.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b8c6071986e332ae6ceffe3b98715f https://doi.org/10.1016/s0960-894x(98)00010-9 Zobrazit plný text záznamu Full Text from ScienceDirect