Urotensin II induces hypertrophic responses in cultured cardiomyocytes from neonatal rats
| Autor: | Ryozo Nagai, Yunzeng Zou, Tsutomu Yamazaki |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Urotensin II
MAPK/ERK pathway medicine.medical_specialty Phenylalanine Urotensins Biophysics Gene Expression Neuropeptide Cardiomegaly Stimulation Cardiomyocyte Biology Biochemistry Muscle hypertrophy chemistry.chemical_compound Atrial natriuretic peptide Structural Biology Internal medicine Natriuretic Peptide Brain Genetics medicine Extracellular Animals Humans Rats Wistar Molecular Biology Cells Cultured Cell Size Myocardium Heart Hypertrophy Cell Biology Brain natriuretic peptide Rats Enzyme Activation Endocrinology Animals Newborn Microscopy Fluorescence chemistry Protein Biosynthesis Mitogen-Activated Protein Kinases Urotensin-II Atrial Natriuretic Factor |
| Zdroj: | FEBS Letters. 508:57-60 |
| ISSN: | 0014-5793 |
| Popis: | Urotensin II (UII), a cyclic neuropeptide, functions not only in the central nervous system but also in non-neural systems including cardiovascular systems. In the present study we examined whether UII regulates hypertrophy in cardiomyocytes. The exposure of cultured cardiomyocytes from neonatal rats to UII dose-dependently activated extracellular signal-regulated kinases (ERKs), important molecules in the development of cardiac hypertrophy. ERK activation by UII at 100 nM peaked at 8 min after stimulation. UII markedly induced expression of specific genes encoding atrial natriuretic peptide and brain natriuretic peptide, and significantly increased amino acid incorporation into proteins. Incubation of cardiomyocytes with UII increased cell size and myofibril organisation. UII, then, might participate in cardiomyocyte hypertrophy. |
| Databáze: | OpenAIRE |
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