New Manzamine Alkaloids with Potent Activity against Infectious Diseases
| Autor: | D. C. Dunbar, Mark T. Hamann, K. A. El Sayed, I. Katsuyama, Michelle Kelly, Kenny K. H. Ang, U. A. K. Kara, Anis A. Khan |
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| Rok vydání: | 2001 |
| Předmět: |
Models
Molecular Carbazoles Molecular Conformation Pharmacology Biochemistry Catalysis Inhibitory Concentration 50 Mice Colloid and Surface Chemistry Anti-Infective Agents In vivo Chloroquine medicine Animals Humans Tuberculosis Antimalarial Agent Artemisinin Haplosclerida biology Chemistry General Chemistry biology.organism_classification In vitro Malaria Porifera Sponge Female Petrosiidae Toxoplasmosis Carbolines medicine.drug |
| Zdroj: | Journal of the American Chemical Society. 123:1804-1808 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | The isolation of the new enantiomers of 8-hydroxymanzamine A (1), manzamine F (2), along with the unprecedented manzamine dimer, neo-kauluamine from an undescribed genus of Indo-Pacific sponge (family Petrosiidae, order Haplosclerida) is reported. The relative stereochemistry of neo-kauluamine was established through detailed analysis of NOE-correlations combined with molecular modeling. The significance of the manzamines as in vivo antimalarial agents with superior activity to the clinically used drugs artemisinin and chloroquine is discussed along with the activity in vitro against the AIDS-opportunistic infectious diseases tuberculosis and toxoplasmosis. Reexamination of the sponges identified as Prianos, and Pachypellina, in earlier publications has confirmed that these are members of the same genus as the sponge described here, but differ at the species level. |
| Databáze: | OpenAIRE |
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