Endocrine and exocrine pancreatic insufficiency after acute pancreatitis: long-term follow-up study
| Autor: | Lu Ke, Weiqin Li, Zhihui Tong, Jingzhu Zhang, Jianfeng Tu, Yue Yang, Guotao Lu, Jieshou Li, Qi Yang, Baiqiang Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Necrosis Exocrine pancreatic insufficiency Gastroenterology Pancreatic necrosis Impaired glucose tolerance Diabetes Complications 03 medical and health sciences 0302 clinical medicine Insulin resistance Endocrine pancreatic insufficiency Risk Factors Internal medicine Diabetes mellitus Glucose Intolerance medicine Endocrine system Humans lcsh:RC799-869 business.industry Follow-up study General Medicine Middle Aged medicine.disease Acute pancreatitis Postprandial Pancreatitis 030220 oncology & carcinogenesis Acute Disease Regression Analysis 030211 gastroenterology & hepatology Female lcsh:Diseases of the digestive system. Gastroenterology medicine.symptom business Research Article Follow-Up Studies |
| Zdroj: | BMC Gastroenterology, Vol 17, Iss 1, Pp 1-9 (2017) BMC Gastroenterology |
| DOI: | 10.1186/s12876-017-0663-0 |
| Popis: | Background Patients could develop endocrine and exocrine pancreatic insufficiency after acute pancreatitis (AP), but the morbidity, risk factors and outcome remain unclear. The aim of the present study was to evaluate the incidence of endocrine and exocrine pancreatic insufficiency after AP and the risk factors of endocrine pancreatic insufficiency through a long-term follow-up investigation. Methods Follow-up assessment of the endocrine and exocrine function was conducted for the discharged patients with AP episodes. Oral Glucose Tolerance Test (OGTT) and faecal elastase-1(FE-1) test were used as primary parameters. Fasting blood-glucose (FBG), fasting insulin (FINS), glycosylated hemoglobin HBA1c, 2-h postprandial blood glucose (2hPG), Homa beta cell function index (HOMA-β), homeostasis model assessment of insulin resistance (HOMA-IR) and FE-1 were collected. Abdominal contrast-enhanced computed tomography (CECT) was performed to investigate the pancreatic morphology and the other related data during hospitalization was also collected. Results One hundred thirteen patients were included in this study and 34 of whom (30.1%) developed diabetes mellitus (DM), 33 (29.2%) suffered impaired glucose tolerance (IGT). Moreover, 33 patients (29.2%) developed mild to moderate exocrine pancreatic insufficiency with 100μg/g50%, WON and insulin resistance were the independent risk factors of new onset diabetes after AP. Electronic supplementary material The online version of this article (10.1186/s12876-017-0663-0) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|