High-throughput exposure modeling to support prioritization of chemicals in personal care products
| Autor: | David E. Meyer, Alexi Ernstoff, Olivier Jolliet, Susan A. Csiszar, Peter Fantke |
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| Rok vydání: | 2016 |
| Předmět: |
Prioritization
Environmental Engineering Health Toxicology and Mutagenesis Population Phthalic Acids Parabens Poison control Cosmetics Skin permeability 010501 environmental sciences Intake fraction Risk Assessment 01 natural sciences Permeability Article Toxicology 0404 agricultural biotechnology Toxicity Tests Humans Environmental Chemistry education Skin 0105 earth and related environmental sciences Chemical content education.field_of_study Models Statistical Toxicity data Ecology Public Health Environmental and Occupational Health Environmental Exposure 04 agricultural and veterinary sciences General Medicine General Chemistry 040401 food science Pollution Chemical used Environmental science Environmental Monitoring |
| Zdroj: | Csiszar, S A, Ernstoff, A, Fantke, P, Meyer, D E & Jolliet, O 2016, ' High-throughput exposure modeling to support prioritization of chemicals in personal care products ', Chemosphere, vol. 163, pp. 490-498 . https://doi.org/10.1016/j.chemosphere.2016.07.065 Chemosphere |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/j.chemosphere.2016.07.065 |
| Popis: | We demonstrate the application of a high-throughput modeling framework to estimate exposure to chemicals used in personal care products (PCPs). As a basis for estimating exposure, we use the product intake fraction (PiF), defined as the mass of chemical taken by an individual or population per mass of a given chemical used in a product. We calculated use- and disposal- stage PiFs for 518 chemicals for five PCP archetypes. Across all product archetypes the use- and disposal- stage PiFs ranged from 10−5 to 1 and 0 to 10−3, respectively. There is a distinction between the use-stage PiF for leave-on and wash-off products which had median PiFs of 0.5 and 0.02 across the 518 chemicals, respectively. The PiF is a function of product characteristics and physico-chemical properties and is maximized when skin permeability is high and volatility is low such that there is no competition between skin and air losses from the applied product. PCP chemical contents (i.e. concentrations) were available for 325 chemicals and were combined with PCP usage characteristics and PiF yielding intakes summed across a demonstrative set of products ranging from 10−8–30 mg/kg/d, with a median of 0.1 mg/kg/d. The highest intakes were associated with body lotion. Bioactive doses derived from high-throughput in vitro toxicity data were combined with the estimated PiFs to demonstrate an approach to estimate bioactive equivalent chemical content and to screen chemicals for risk. |
| Databáze: | OpenAIRE |
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