Prognostic factors and long-term survival in 585 patients with metastatic breast cancer treated with epirubicin-based chemotherapy
| Autor: | P. Dombernowsky, Dorte Nielsen, M. Ryberg, K. Østerlind, T. Skovsgaard |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Oncology
Adult medicine.medical_specialty medicine.medical_treatment Health Status Breast Neoplasms Metastasis Risk Factors Internal medicine medicine Humans Neoplasm Metastasis Survival analysis Aged Retrospective Studies Chemotherapy Performance status L-Lactate Dehydrogenase business.industry Bone metastasis Hematology Middle Aged medicine.disease Prognosis Metastatic breast cancer Chemotherapy regimen Survival Analysis Surgery Receptors Estrogen Female Neoplasm Recurrence Local business Epirubicin medicine.drug |
| Zdroj: | Annals of oncology : official journal of the European Society for Medical Oncology. 12(1) |
| ISSN: | 0923-7534 |
| Popis: | Summary Background Analysis of prognostic factors in patients with metastatic breast cancer treated with epirubicin-based chemotherapy Patients and methods Data from 469 patients treated with epirubicin-based chemotherapy for metastatic breast cancer were used Prognostic factors were identified (Cox multivariate analysis). A prognostic index was compiled and risk groups were established accordingly. The applicability of the index was investigated in a series of 116 patients Results The prognostic factors identified were, liver, pleural, soft tissue, lung and bone metastases, performance status > 2, advancing age, abnormal elevation of serum lactate dehydrogenase and negative/unknown oestrogen receptor status. Four risk groups were established good, intermediate 1, intermediate II and poor The median and five-year survivals in percentage were, good 34 months (26%), intermediate 1: 19 months (6%), intermediate II. 12 months (0%); poor. 7 months (1%) The corresponding values in the applicability group were 32 months (23%), 28 months (22%), 18 months (5%); and 6 months (0%) Conclusions It is more the number and impact on the organs involved, that predict the patients’ survival The construction of a prognostic index could be helpful in assessing the outlook for patients, especially the quite dramatic difference in long-term survival between the good and poor risk patients |
| Databáze: | OpenAIRE |
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