Copper-64 based radiopharmaceuticals for brain tumors and hypoxia imaging
| Autor: | Alessandra Boschi, Micol Pasquali, Joao A. Osso, Amir Reza Jalilian, Petra Martini, Arman Shahi |
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| Rok vydání: | 2020 |
| Předmět: |
Thiosemicarbazones
Neuroimaging NO 030218 nuclear medicine & medical imaging Structure-Activity Relationship 03 medical and health sciences 0302 clinical medicine Isotopes Coordination Complexes Nickel medicine Animals Humans Radiology Nuclear Medicine and imaging Hypoxia Radionuclide Imaging Solid tumor copper-64 Brain Neoplasms business.industry Production cost glioblastoma Primary malignancy Hypoxia (medical) medicine.disease copper-64 Brain neoplasms Neuroimaging glioblastoma radiopharmaceuticals Copper Radioisotopes Positron-Emission Tomography Diagnostic agent Cancer research Zinc Isotopes Copper-64 Radiopharmaceuticals medicine.symptom business Evidence synthesis Glioblastoma |
| Zdroj: | The Quarterly Journal of Nuclear Medicine and Molecular Imaging. 64 |
| ISSN: | 1827-1936 1824-4785 |
| DOI: | 10.23736/s1824-4785.20.03285-9 |
| Popis: | Introduction The most common and aggressive primary malignancy of the central nervous system is Glioblastoma that, as a wide range of malignant solid tumor, is characterized by extensive hypoxic regions. A great number of PET radiopharmaceuticals have been developed for the identification of hypoxia in solid tumors, among these, we find copper-based tracers. The aim of the current review paper was to provide an overview of radiocopper compounds applied for preclinical and clinical research in brain tumors and hypoxia imaging or therapy. Evidence acquisition Copper offers a wide variety of isotopes, useful for nuclear medicine applications, but only 64Cu and 67Cu are under the spotlight of the scientific community since being good candidates for theranostic applications. Between the two, 64Cu availability and production cost have attracted more interest of the scientific community. Evidence synthesis In order to better understand the application of copper-bis thiosemicarbazones in hypoxia imaging, an overview of the role of hypoxia in cancer, existing non-imaging and imaging techniques for hypoxia identification and promising future avenues regarding hypoxia is necessary. Different proposed uptake mechanisms of [64Cu][Cu(ATSM)] inside the cell will be discussed and other 64Cu-based tracers for brain tumors described. Conclusions Among radio copper compounds [64Cu][Cu(ATSM)] is the most studied radiopharmaceutical for imaging and treatment of brain tumors. Experimental evidence suggested that [64Cu][Cu(ATSM)] could be more appropriately considered as a marker of over-reduced intracellular state rather than a pure hypoxia agent. Moreover, preliminary clinical data suggested that [64Cu]CuCl 2 can be a potentially useful diagnostic agent for malignancies of the central nervous system (CNS). |
| Databáze: | OpenAIRE |
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