An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore
Autor: | Chen Seong Wong, Li Wei Ang, Yee Sin Leo, Irving Charles Boudville, Oon Tek Ng |
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Přispěvatelé: | Lee Kong Chian School of Medicine (LKCMedicine), National Centre for Infectious Diseases, Tan Tock Seng Hospital |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
RNA viruses
Male 0301 basic medicine HIV Infections Pathology and Laboratory Medicine Geographical Locations 0302 clinical medicine Immunodeficiency Viruses Prevalence Public and Occupational Health 030212 general & internal medicine Young adult Metabolic Syndrome Singapore education.field_of_study Multidisciplinary Antimicrobials Pharmaceutics Drugs Antiretrovirals HIV diagnosis and management Middle Aged Antivirals Prognosis Vaccination and Immunization Medical Microbiology Viral Pathogens Viruses Infectious diseases Medicine Female Pathogens Human Immunodeficiency Virus Research Article Medical conditions Adult medicine.medical_specialty Asia Adolescent Anti-HIV Agents Science Immunology 030106 microbiology Population Antiretroviral Therapy Viral diseases Microbiology Young Adult 03 medical and health sciences Antiviral Therapy Drug Therapy Microbial Control Virology Diabetes mellitus Internal medicine Retroviruses medicine Humans Medicine [Science] education Microbial Pathogens Aged Retrospective Studies Medicine and health sciences Pharmacology business.industry Lentivirus Hypertriglyceridemia Organisms Biology and Life Sciences HIV Retrospective cohort study medicine.disease Obesity Diagnostic medicine Hypocholesterolemia Metabolic Disorders People and Places Preventive Medicine Metabolic syndrome business Follow-Up Studies |
Zdroj: | PLoS ONE, Vol 16, Iss 6, p e0252320 (2021) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | BackgroundWhile the use of combination antiretroviral therapy (cART) has conferred significant reduction in morbidity and mortality, there are growing concerns about the metabolic complications of antiretroviral regimens in HIV-infected patients. The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) among people living with HIV (PLHIV) in Singapore.MethodsWe conducted a retrospective study using the clinical database maintained by the Clinical HIV Programme at the National Centre for Infectious Diseases, Singapore. Treatment-experienced PLHIV on follow-up during 2015–2017 were included. MetS was defined as having three or more of the following five abnormalities: hypertriglyceridemia, HDL hypocholesterolemia, hypertension, obesity, and diabetes.ResultsA total of 2,231 PLHIV were included in this study. 93.9% were men, and the median age at latest follow-up was 48 years. The median duration of HIV infection and duration of exposure to cART was 6.8 years and 5.7 years, respectively. All had been exposed to nucleoside reverse transcriptase inhibitors (NRTIs) as the first line of treatment, 93.9% to non-NRTIs, 28.6% to protease inhibitors (PIs) and 12.8% to integrase strand transfer inhibitors. The most common metabolic abnormality among PLHIV was HDL hypocholesterolemia (60.2%) followed by hypertriglyceridemia (45.5%). Of all the 2,231 individuals, 68.8% had at least one component of MetS. The overall prevalence of MetS was 23.6% (95% confidence interval 21.9%–25.4%). Of the 526 with MetS, the most common combination was HDL hypocholesterolemia, hypertriglyceridemia and hypertension (51.0%), followed by HDL hypocholesterolemia, hypertriglyceridemia, hypertension and diabetes (25.1%). Compared with PLHIV without MetS, a significantly higher proportion of those with MetS were ever on protease inhibitors (33.5% vs. 27.1%).ConclusionMetS is common in PLHIV. In view of the progressive aging of HIV-infected population and long-term use of cART, regular monitoring for metabolic abnormalities, surveillance of drug effects and behavioural interventions are needed to optimize management and prevention of metabolic disorders in PLHIV. |
Databáze: | OpenAIRE |
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