An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore

Autor: Chen Seong Wong, Li Wei Ang, Yee Sin Leo, Irving Charles Boudville, Oon Tek Ng
Přispěvatelé: Lee Kong Chian School of Medicine (LKCMedicine), National Centre for Infectious Diseases, Tan Tock Seng Hospital
Jazyk: angličtina
Rok vydání: 2021
Předmět:
RNA viruses
Male
0301 basic medicine
HIV Infections
Pathology and Laboratory Medicine
Geographical Locations
0302 clinical medicine
Immunodeficiency Viruses
Prevalence
Public and Occupational Health
030212 general & internal medicine
Young adult
Metabolic Syndrome
Singapore
education.field_of_study
Multidisciplinary
Antimicrobials
Pharmaceutics
Drugs
Antiretrovirals
HIV diagnosis and management
Middle Aged
Antivirals
Prognosis
Vaccination and Immunization
Medical Microbiology
Viral Pathogens
Viruses
Infectious diseases
Medicine
Female
Pathogens
Human Immunodeficiency Virus
Research Article
Medical conditions
Adult
medicine.medical_specialty
Asia
Adolescent
Anti-HIV Agents
Science
Immunology
030106 microbiology
Population
Antiretroviral Therapy
Viral diseases
Microbiology
Young Adult
03 medical and health sciences
Antiviral Therapy
Drug Therapy
Microbial Control
Virology
Diabetes mellitus
Internal medicine
Retroviruses
medicine
Humans
Medicine [Science]
education
Microbial Pathogens
Aged
Retrospective Studies
Medicine and health sciences
Pharmacology
business.industry
Lentivirus
Hypertriglyceridemia
Organisms
Biology and Life Sciences
HIV
Retrospective cohort study
medicine.disease
Obesity
Diagnostic medicine
Hypocholesterolemia
Metabolic Disorders
People and Places
Preventive Medicine
Metabolic syndrome
business
Follow-Up Studies
Zdroj: PLoS ONE, Vol 16, Iss 6, p e0252320 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: BackgroundWhile the use of combination antiretroviral therapy (cART) has conferred significant reduction in morbidity and mortality, there are growing concerns about the metabolic complications of antiretroviral regimens in HIV-infected patients. The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) among people living with HIV (PLHIV) in Singapore.MethodsWe conducted a retrospective study using the clinical database maintained by the Clinical HIV Programme at the National Centre for Infectious Diseases, Singapore. Treatment-experienced PLHIV on follow-up during 2015–2017 were included. MetS was defined as having three or more of the following five abnormalities: hypertriglyceridemia, HDL hypocholesterolemia, hypertension, obesity, and diabetes.ResultsA total of 2,231 PLHIV were included in this study. 93.9% were men, and the median age at latest follow-up was 48 years. The median duration of HIV infection and duration of exposure to cART was 6.8 years and 5.7 years, respectively. All had been exposed to nucleoside reverse transcriptase inhibitors (NRTIs) as the first line of treatment, 93.9% to non-NRTIs, 28.6% to protease inhibitors (PIs) and 12.8% to integrase strand transfer inhibitors. The most common metabolic abnormality among PLHIV was HDL hypocholesterolemia (60.2%) followed by hypertriglyceridemia (45.5%). Of all the 2,231 individuals, 68.8% had at least one component of MetS. The overall prevalence of MetS was 23.6% (95% confidence interval 21.9%–25.4%). Of the 526 with MetS, the most common combination was HDL hypocholesterolemia, hypertriglyceridemia and hypertension (51.0%), followed by HDL hypocholesterolemia, hypertriglyceridemia, hypertension and diabetes (25.1%). Compared with PLHIV without MetS, a significantly higher proportion of those with MetS were ever on protease inhibitors (33.5% vs. 27.1%).ConclusionMetS is common in PLHIV. In view of the progressive aging of HIV-infected population and long-term use of cART, regular monitoring for metabolic abnormalities, surveillance of drug effects and behavioural interventions are needed to optimize management and prevention of metabolic disorders in PLHIV.
Databáze: OpenAIRE
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