Benign prostate hyperplasia as a potential protective factor against prostate cancer: Insights from a magnetic resonance imaging study of compositional characteristics
| Autor: | Jason Hafron, Robert Colvin, Sirisha R Nandalur, David Gangwish, Brian Seifman, Kiran R. Nandalur, David Walker |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Urology medicine.medical_treatment Prostatic Hyperplasia Logistic regression Prostate cancer Prostate Biopsy Medicine Effective diffusion coefficient Humans Aged Prostatectomy medicine.diagnostic_test business.industry Prostatic Neoplasms Magnetic resonance imaging Hyperplasia Middle Aged Protective Factors medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Oncology business |
| Zdroj: | The ProstateREFERENCES. 81(14) |
| ISSN: | 1097-0045 |
| Popis: | PURPOSE The structural relationship between benign prostate hyperplasia (BPH) and prostate cancer (Pca) is controversial. The purpose of our study was to examine the association between quantitative prostate compositional metrics by magnetic resonance imaging (MRI) and Pca. METHODS We identified 405 patients who underwent prostate MRI and biopsy and/or prostatectomy from January 2019 to January 2021 at our institution. Segmentation volumetric methods were used to assess central gland (CG) and peripheral zone (PZ) volume. PZ mean thickness and mean apparent diffusion coefficient (ADC), marker of underlying histologic components, were measured. Multivariable logistic regression was performed with outcomes of ≥Grade Group (GG) 2 Pca and for multifocal disease. RESULTS On multivariable analysis, higher CG volumes were at lower odds of ≥GG2 disease (n = 227) (OR: 0.97, 95% CI 0.96-0.98, p |
| Databáze: | OpenAIRE |
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