Investigating the role of the IGF axis as a predictor of biochemical recurrence in prostate cancer patients post-surgery
| Autor: | Lauren Brady, Yue Fan, Noel M. Fitzgerald, Ann Treacy, R. William G. Watson, Ciara Barrett, John M. Fitzpatrick, Lisa N. Murphy, Brian D. Hayes, Mardiana Abdul Aziz, Elaine W. Kay, Susie Boyce, Kieran J. Breen, Amanda O'Neill, Emma R. Dorris, Stephen P. Finn |
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| Rok vydání: | 2017 |
| Předmět: |
Biochemical recurrence
Adult Male Urology 030232 urology & nephrology Receptor IGF Type 1 Cohort Studies 03 medical and health sciences Prostate cancer 0302 clinical medicine Predictive Value of Tests hemic and lymphatic diseases medicine Adjuvant therapy Biomarkers Tumor PTEN Humans Protein kinase B Aged Prostatectomy Tissue microarray biology breakpoint cluster region PTEN Phosphohydrolase Prostatic Neoplasms Middle Aged medicine.disease Receptor Insulin 3. Good health Oncology 030220 oncology & carcinogenesis biology.protein Cancer research Immunohistochemistry Neoplasm Recurrence Local Proto-Oncogene Proteins c-akt |
| Zdroj: | The Prostate. 77(12) |
| ISSN: | 1097-0045 |
| Popis: | Background Between 20% and 35% of prostate cancer (PCa) patients who undergo treatment with curative intent (ie, surgery or radiation therapy) for localized disease will experience biochemical recurrence (BCR). Alterations in the insulin-like growth factor (IGF) axis and PTEN expression have been implicated in the development and progression of several human tumors including PCa. We examined the expression of the insulin receptor (INSR), IGF-1 receptor (IGF-1R), PTEN, and AKT in radical prostatectomy tissue of patients who developed BCR post-surgery. Methods Tissue microarrays (TMA) of 130 patients post-radical prostatectomy (65 = BCR, 65 = non-BCR) were stained by immunohistochemistry for INSR, IGF-1R, PTEN, and AKT using optimized antibody protocols. INSR, IGF1-R, PTEN, and AKT expression between benign and cancerous tissue, and different Gleason grades was assessed. Kaplan-Meier survival curves were used to examine the relationship between proteins expression and BCR. Results INSR (P |
| Databáze: | OpenAIRE |
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