Supramolecular Sensor for Cancer-Associated Nitrosamines
| Autor: | Yuji Kubo, Nina A. Esipenko, Ryuhei Nishiyabu, Maria E. Kozelkova, Ben Zhang, Pavel Anzenbacher, Lyle Isaacs, Tsuyoshi Minami |
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| Rok vydání: | 2012 |
| Předmět: |
Bridged-Ring Compounds
Models Molecular Nitrosamines Molecular Structure Macromolecular Substances Stereochemistry Chemistry Imidazoles Supramolecular chemistry macromolecular substances General Chemistry Biochemistry Combinatorial chemistry Fluorescence Information density Catalysis Colloid and Surface Chemistry Neoplasms Molecule Fluorescent Dyes |
| Zdroj: | Journal of the American Chemical Society. 134:20021-20024 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja3102192 |
| Popis: | A supramolecular assay based on two fluorescent cucurbit[n]uril probes enables the recognition and quantification of nitrosamines, including cancer-associated nitrosamines, compounds that are difficult to recognize. The cross-reactive sensor leverages weak interactions and competition among the probe, metal, and guest, yielding high information density in the signal output (variance) and enabling the recognition of structurally similar guests. |
| Databáze: | OpenAIRE |
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