DNA Double Strand Breaks: A Common Theme in Neurodegenerative Diseases
Autor: | Cristiana Mollinari, Alessio Cardinale, Daniela Merlo, Mauro Racaniello, Enrico Garaci |
---|---|
Rok vydání: | 2015 |
Předmět: |
0301 basic medicine
Parkinson's disease DNA Repair DNA repair DNA damage Disease Biology Bioinformatics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Huntington's disease medicine Animals Humans DNA Breaks Double-Stranded Neurodegeneration Neurodegenerative Diseases medicine.disease Disease Models Animal 030104 developmental biology Neurology chemistry Apoptosis Cancer research Neurology (clinical) 030217 neurology & neurosurgery DNA DNA Damage |
Zdroj: | Current Alzheimer research. 13(11) |
ISSN: | 1875-5828 |
Popis: | Accumulation of DNA damage and impairment of DNA repair systems are involved in the pathogenesis of different neurodegenerative diseases. Whenever DNA damage is too extensive, the DNA damage response pathway provides for triggering cellular senescence and/or apoptosis. However, whether the increased level of DNA damage in neurodegenerative disorders is a cause rather than the consequence of neurodegenerative events remains to be established. Among possible DNA lesions, DNA double strand breaks (DSBs) are rare events, nevertheless they are the most lethal form of DNA damage. In neurons, DSBs are particularly deleterious because of their reduced DNA repair capability as compared to proliferating cells. Here, we provide a description of DSB repair systems and describe human studies showing the presence of several types of DNA lesions in three major neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). Then, we analyze the role of DSB accumulation and deficiency of DSB repair systems in neurodegeneration by examining studies on animal models of neurodegenerative diseases. |
Databáze: | OpenAIRE |
Externí odkaz: |