No evidence for genetic association of interferon regulatory factor 3 in systemic lupus erythematosus
| Autor: | L Micó, Miguel A. López-Nevot, Carles Tolosa, M. T. Camps, Francisco Hernandez, Ana Suárez, Juan Jiménez-Alonso, José Luis Callejas-Rubio, M F González-Escribano, Elena Sánchez, Javier Martín, E de Ramón, M. Á González-Gay, Norberto Ortego-Centeno, Rosa Garcia-Portales, Carmen Gutiérrez, José Mario Sabio, Julio Sánchez-Román |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Adolescent Genotype White People Young Adult Rheumatology Polymorphism (computer science) medicine Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease Allele Genetic association Autoimmune disease Lupus erythematosus Polymorphism Genetic business.industry Haplotype Middle Aged medicine.disease Immunology Population study Female Interferon Regulatory Factor-3 business |
| Zdroj: | Lupus. 18(3) |
| ISSN: | 0961-2033 |
| Popis: | The aim of this study was to determine the potential role of three IRF3 gene polymorphisms (rs2304204, rs7251 and rs2304207) with systemic lupus erythematosus (SLE). Our study population consisted of 610 patients with SLE and 730 healthy controls. All individual were of Spanish Caucasian origin. The IRF3 polymorphisms were genotyped using a PCR system with pre-developed TaqMan allelic discrimination assay. No statistically significant differences were found when allele and genotype distribution of rs2304204, rs7251 and rs2304207 polymorphisms were compared between patients with SLE and controls [overall P values: rs7251, P = 0.06; rs2304204, P = 0.26 and rs2304207, P = 0.36, by chi-squared test on a 3 × 2 contingency table. Overall allelic P values: rs7251, P = 0.8, OR (95%CI) = 1.03 (0.87–1.22); rs2304204, P = 0.2, OR (95%CI) = 1.12 (0.93–1.34) and rs2304207, P = 0.8, OR (95%CI) = 1.02 (0.82–1.26)]. In addition, no evidence of association with haplotypes and clinical features of SLE was found. Our data suggest that the IRF3 polymorphisms do not appear to play a major role in the susceptibility or severity of SLE in a Spanish population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|