Decreased vitamin D serum levels at melanoma diagnosis are associated with tumor ulceration and high tumor mitotic rate
| Autor: | Victor Traves, Esperanza Manrique-Silva, Celia Requena, Oscar M. Moreno-Arrones, Michael Gerbo, Josh Zegeer, Eduardo Nagore |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Cancer Research medicine.medical_specialty Skin Neoplasms Mitosis Dermatology Gastroenterology vitamin D deficiency Breslow Thickness Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Vitamin D and neurology Humans Medicine Prospective Studies Vitamin D Melanoma Aged Aged 80 and over business.industry Odds ratio Middle Aged medicine.disease Confidence interval Cross-Sectional Studies 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis Female Calcifediol business Body mass index |
| Zdroj: | Melanoma Research. 29:664-667 |
| ISSN: | 0960-8931 |
| DOI: | 10.1097/cmr.0000000000000638 |
| Popis: | The aim of this study is to evaluate the relation between 25-hydroxyvitamin D levels at diagnosis and pathological characteristics in primary invasive melanoma. A cross-sectional study was designed based on a series of 204 consecutive patients diagnosed of invasive melanomas in the 2013-2017 period at a single institution. 25-hydroxyvitamin D serum levels at diagnosis were assessed, and three groups were defined by vitamin D status: deficiency, insufficiency, and sufficiency. Clinical and pathological characteristics were compared between the groups by Chi-square test. Logistic regression models were performed to evaluate the association between vitamin D status and Breslow thickness, ulceration, and tumor mitotic rate. A significant association between vitamin D levels at diagnosis and location, tumor mitotic rate, and ulceration was found; and a borderline association with Breslow thickness and BMI. Deficient levels were found in 7.8% of patients and increased the risk of presenting ulcerated tumors [odds ratio: 6.8 (95% confidence interval: 1.5-29.7; P = 0.012)] and with a tumor mitotic rate greater than 1 mitosis/mm [odds ratio: 6.0 (95% confidence interval: 1.4-25.1; P = 0.014)]. A marginal increased risk of tumor thickness greater than 1 mm was also observed [odds ratio: 3.7 (95% confidence interval: 1.0-13.9; P = 0.057)]. Our study suggests a role of vitamin D levels in melanoma aggressiveness and raises the question as to whether vitamin D levels should be monitored, or even supplemented, in people with low yearly sun exposure. |
| Databáze: | OpenAIRE |
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