Analysis of the Possible Persistent Genotoxic Damage in Workers Linked to the Ardystil Syndrome
| Autor: | José Miguel Soriano, José Cervera, Valentín Esteban, M. Almonacid, Esperanza Such, Alegría Montoro, Gumersindo Verdú, Joan Francesc Barquinero, Natividad Sebastià, Jose Bonafont, David Hervás, J. I. Villaescusa |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Health impact Physiology Sister chromatid exchange INGENIERIA NUCLEAR Toxicology 03 medical and health sciences Occupational Exposure Humans Medicine Genetics (clinical) business.industry Significant difference Healthy subjects Outbreak Syndrome General Medicine Respiration Disorders 030104 developmental biology Textile Industry Distribution pattern Biomarker (medicine) Female business Sister Chromatid Exchange DNA Damage |
| Zdroj: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname GENETIC TESTING AND MOLECULAR BIOMARKERS r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe |
| ISSN: | 1945-0257 1945-0265 |
| Popis: | [EN] Background: A combination of several factors including a change in the paint application system; a lack of proper hygiene; and inadequate safety measures caused a severe health impact in the workers of some textile painting factories. This outbreak, mainly characterized by respiratory disorders, caused the death of six people and it has been classified as Ardystil syndrome. Materials and Methods: Fifty-two workers involved in the outbreak and 48 healthy subjects not known to have exposed to the potentially mutagenic agents participated in the study. The program evaluated possible genotoxic damage through the sister chromatid exchange (SCE) cytogenetic biomarker assay. We determined the frequency of SCE, high-frequency cells (HFCs), and a ratio, which can be considered as a new parameter, allowing for the study of the SCE distribution pattern among the chromosomes. Results: There was no statistically significant difference in the SCE frequency and in the mean number of HFCs between the control and the Ardystil-affected groups. However, smoking increased the incidence of all parameters studied in both the case and control groups. Conclusions: This study shows that workers involved in the Ardystil syndrome did not suffer genotoxic damage as measured by SCE and HFCs when compared with the control group. This research was supported, in part, by Hospital Universitario Politecnico La Fe de Valencia and Conselleria de Sanidad de Valencia. The authors would like to dedicate this article to the memory of Dr. Miguel Almonacid Bujeda, a superb individual, with whom they had the good fortune to work with for a number of years. |
| Databáze: | OpenAIRE |
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