Myeloperoxidase as cardiovascular risk marker in pre-pubertal preterm children?

Autor: Fabíola Isabel Suano-Souza, Simone Holzer, Denise de Oliveira Schoeps, Sonia Hix, Fernando Luiz Affonso Fonseca, Roseli Oselka Saccardo Sarni
Rok vydání: 2019
Předmět:
Blood Glucose
Male
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Medicine (miscellaneous)
Physiology
030204 cardiovascular system & hematology
Child Development
0302 clinical medicine
Risk Factors
Birth Weight
Infant
Very Low Birth Weight
Insulin
Child
Nutrition and Dietetics
biology
Age Factors
Gestational age
Up-Regulation
C-Reactive Protein
Myeloperoxidase
Female
Inflammation Mediators
Child Nutritional Physiological Phenomena
Cardiology and Cardiovascular Medicine
Infant
Premature
Birth weight
Nutritional Status
Gestational Age
030209 endocrinology & metabolism
Risk Assessment
03 medical and health sciences
Insulin resistance
medicine
Humans
Peroxidase
Full Term
Inflammation
business.industry
Cholesterol
HDL
Infant
Newborn
Paraoxonase
Anthropometry
Atherosclerosis
medicine.disease
Oxidative Stress
Cross-Sectional Studies
Case-Control Studies
biology.protein
Insulin Resistance
business
Biomarkers
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases. 29:1345-1352
ISSN: 0939-4753
DOI: 10.1016/j.numecd.2019.08.012
Popis: To evaluate the biomarkers related to cardiovascular risk in pre-pubertal preterm children with a birth weight of less than 1,500 g and relate them to current nutritional status, insulin resistance, and inflammation.This is a cross-sectional, controlled study with pre-pubertal preterm children aged 5-9 years with a birth weight of less than 1500 g (Preterm group, n = 44) compared to full term children of adequate weight for gestational age (Control group, n = 30). Clinical evaluation: anthropometry and pubertal staging. Laboratory tests: total cholesterol and fractions, triglycerides, paraoxonase 1, apolipoproteins A-I and B, myeloperoxidase (MPO), high sensitivity C-reactive protein (hs-CRP), glycemia and insulin (to calculate HOMA-IR). In the preterm group, 19 (43.2%) were male, with mean birth weight and gestational age of 1157 ± 242 g and 30.0 ± 2.3 weeks, respectively. The preterm group showed lower concentrations of HDL-c (60.1 ± 10.1 vs. 69.0 ± 10.0 mg/dL; p 0.001); higher concentrations of hs-CRP [0.55 mg/dL (0.30; 39.4) vs. 0.30 mg/dL (0.30; 10.80); p = 0.043], of MPO [21.1 ng/mL (5.7; 120.0) vs. 8.1 ng/mL (2.6; 29.6); p 0.001] and of MPO/HDL-c ratio [0.39 (0.09; 2.07) ng/mg vs. 0.11 (0.05; 0.58)]. The MPO/HDL-c ratio was the variable that showed the best discriminatory power between the groups (AUC = 0.878; 95% CI; 0.795-0.961). MPO concentrations in the preterm group were correlated with those of hs-CRP (r = 0.390; p = 0.009), insulin (r = 0.448; p = 0.002) and HOMA-IR (r = 0.462; p = 0.002).Prepubertal preterm children show high MPO concentrations and MPO/HDL-c ratio that are associated with inflammation and oxidative stress, which, in turn, may be associated with atherosclerosis.
Databáze: OpenAIRE
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