Impaired light masking in dopamine D2 receptor-null mice
| Autor: | Masao Doi, Emanuele Tirotta, Monica Malerba, Irene Yujnovsky, Paolo Sassone-Corsi, Jun Hirayama, Emiliana Borrelli |
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| Přispěvatelé: | Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I, Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Masking (art)
Light Dopamine Endogeny Pineal Gland MESH: Mice Knockout Mice Pineal gland 0302 clinical medicine MESH: Receptors Dopamine D2 MESH: Arylalkylamine N-Acetyltransferase MESH: Animals MESH: Brain Chemistry Melatonin MESH: Melatonin Mice Knockout 0303 health sciences Suprachiasmatic nucleus General Neuroscience MESH: Pineal Gland Brain MESH: Motor Activity Circadian Rhythm medicine.anatomical_structure MESH: Photic Stimulation Suprachiasmatic Nucleus medicine.drug MESH: Suprachiasmatic Nucleus MESH: Dopamine Motor Activity Biology Arylalkylamine N-Acetyltransferase 03 medical and health sciences MESH: Brain Dopamine receptor D2 medicine Animals Circadian rhythm MESH: Circadian Rhythm MESH: Mice 030304 developmental biology Brain Chemistry Receptors Dopamine D2 [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology MESH: Light Neuroscience Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | Nature Neuroscience Nature Neuroscience, Nature Publishing Group, 2006, 9 (6), pp.732-4. ⟨10.1038/nn1711⟩ |
| ISSN: | 1097-6256 1546-1726 |
| DOI: | 10.1038/nn1711⟩ |
| Popis: | International audience; Disruption of overt circadian rhythms can occur without influencing the endogenous pacemaker, the so-called 'masking' effect classically elicited by light. As the physiological pathways involved in light masking remain elusive, we analyzed mice lacking the dopamine D2 receptor. Although circadian rhythmicity was normal, D2R-null mice showed a markedly deficient light masking response, indicating that D2R-mediated signaling is an essential component of the neuronal pathways leading to light masking of circadian rhythms. |
| Databáze: | OpenAIRE |
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