Antioxidative Action of the Nitrovasodilator Nicorandil: Inhibition of Oxidative Activation of Liver Microsomal Glutathione S-Transferase and Lipid Peroxidation
Autor: | A, Naito, Y, Aniya, M, Sakanashi |
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Rok vydání: | 1994 |
Předmět: |
Male
Niacinamide Pharmacology Sympathetic Nervous System Dose-Response Relationship Drug Vasodilator Agents Isosorbide Dinitrate Antioxidants Rats Enzyme Activation Nicorandil Propanolamines Rats Sprague-Dawley Nitroglycerin Structure-Activity Relationship Reperfusion Injury Microsomes Liver Animals Lipid Peroxidation Oxidation-Reduction Glutathione Transferase |
Zdroj: | Japanese Journal of Pharmacology. 65:209-213 |
ISSN: | 0021-5198 |
DOI: | 10.1016/s0021-5198(19)35751-8 |
Popis: | Antioxidative effects of the nitrovasodilator nicorandil (SG-75) and denitrated SG-75 (SG-86) were examined in vivo and in vitro. When the isolated rat liver was reperfused with Krebs-Henseleit solution after a 90-min ischemia, microsomal GSH S-transferase activity was increased significantly by oxidative modification of the sulfhydryl group of the enzyme. The increase in the transferase activity after ischemia/reperfusion was depressed by SG-75 but not by SG-86. Furthermore, only SG-75 significantly inhibited lipid peroxidation and the activation of microsomal GSH S-transferase induced by hydrogen peroxide treatment of liver microsomes. These data indicate that SG-75 has an antioxidative action and the nitro group of SG-75 may play a critical role for this action. |
Databáze: | OpenAIRE |
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