Polyoxometalate nanostructured gold surfaces for sensitive biosensing of benzo[a]pyrene
| Autor: | Dimitri Mercier, Michèle Salmain, Maroua Ben Haddada, Souhir Boujday, Dietmar Knopp, Anna Proust, Maria Huebner, Reinhard Niessner |
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| Přispěvatelé: | Science et Ingénierie des Matériaux et Procédés (SIMaP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Réactivité de Surface (LRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Karlsruhe Institute of Technology (KIT), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Laboratoire Charles Friedel, Université Pierre et Marie Curie - Paris 6 (UPMC)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Parisien de Chimie Moléculaire (IPCM), This work was co-financially supported by ANR, Agence Nationale de la Recherche (France) and DFG, Deutsche Forschungsgemeinschaft (Germany), ANR-DFG program, project NArBioS, Grant no.: ANR-11-INTB-1013. |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Polyoxometalate
Chemistry Inorganic chemistry Metals and Alloys Substrate (chemistry) Quartz crystal microbalance QCM-D Condensed Matter Physics Combinatorial chemistry Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Benzo[a]pyrene Covalent bond Monolayer Materials Chemistry Pyrene [CHIM]Chemical Sciences Amine gas treating Electrical and Electronic Engineering Instrumentation Biosensor Nanostructuration |
| Zdroj: | Sensors and Actuators B: Chemical Sensors and Actuators B: Chemical, Elsevier, 2015, 209, pp.770-774. ⟨10.1016/j.snb.2014.12.015⟩ Sensors and Actuators B: Chemical, 2015, 209, pp.770-774. ⟨10.1016/j.snb.2014.12.015⟩ |
| ISSN: | 0925-4005 |
| Popis: | International audience; We report the design of a polyoxometalate-nanostructured immunosensor for benzo[a]pyrene (B[a]P) detection. The organic–inorganic hybrid polyoxometalate (POM) (NBu4)3[PW11O39{(SiC6H4NH2)2O}] carrying two amine functions was covalently attached to a functionalized gold substrate to achieve a nanometric organization of amine groups at its surface. Pyrenebutyric acid (PBA) was subsequently grafted to amine groups to create the sensing layer. The detection of B[a]P in the indirect competitive format was carried out using a monoclonal anti-B[a]P antibody whose binding to the immunoprobe was monitored with a quartz crystal microbalance with dissipation measurement (QCM-D). The performances of the POM-nanostructured biosensor were compared to a reference sensor constructed from a cysteamine self-assembled monolayer. QCM-D measurements displayed significant input from POM-nanostructuration. Both the accessibility of the analogue on the surface and the analytical performances were enhanced showing a promising effect of this strategy of nanostructuration for the biosensing of small molecules. |
| Databáze: | OpenAIRE |
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